Document Detail

Effect of a six-hour marathon ultra-race on the levels of IL-6, LIF, and SCF.
MedLine Citation:
PMID:  20396801     Owner:  NLM     Status:  MEDLINE    
The effects of 6-h marathon ultra-race (long aerobic work below the lactate threshold level) on the levels of IL-6, leukemia inhibiting factor (LIF), and stem cell growth factor (SCF) were studied. The athletes participating in the study had different endurance levels evaluated by the distance covered over 6 h. The level of IL-6 sharply increased after exercise. The degree of IL-6 increase correlated with the length of the distance covered (r=0.83, p=0.042). The concentration of LIF after exercise inversely correlated with the distance covered (r=-0.75), but this correlation was statistically insignificant. The IL-6/LIF proportion exhibited the highest correlation with the result in the marathon ultra-race. This parameter most fully characterized athlete endurance (r=0.92, p=0.009). Hence, the relationship of LIF with physical endurance was demonstrated. Involvement of LIF in antibody production processes can be responsible for it.
A E Donnikov; M Yu Shkurnikov; E B Akimov; E S Grebenyuk; S A Khaustova; E M Shahmatova; A G Tonevitsky
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  148     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  819-21     Citation Subset:  IM    
Institute of Physical Culture and Athletics, Moscow, Russia.
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MeSH Terms
Interleukin-6 / blood*
Leukemia Inhibitory Factor / blood*
Malondialdehyde / blood
Physical Endurance* / immunology,  physiology
Running / physiology*
Stem Cell Factor / blood*
Reg. No./Substance:
0/Interleukin-6; 0/LIF protein, human; 0/Leukemia Inhibitory Factor; 0/Stem Cell Factor; 542-78-9/Malondialdehyde

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