Document Detail

Effect of a single, oral, high-dose vitamin D supplementation on endothelial function in patients with peripheral arterial disease: a randomised controlled pilot study.
MedLine Citation:
PMID:  22831874     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Apart from its role in bone metabolism, vitamin D may also influence cardiovascular disease. The objective of this study was: (1) to determine the effect of a single, oral, high-dose vitamin D supplementation on endothelial function and arterial stiffness in patients with peripheral arterial disease (PAD) and (2) to investigate the impact of this supplementation on coagulation and inflammation parameters.
METHODS: In this double-blind, placebo-controlled, interventional pilot study, we screened 76 Caucasian patients with PAD for vitamin D deficiency. Sixty-two were randomised to receive a single, oral supplementation of 100,000 IU vitamin D3 or placebo. At baseline and after 1 month, we measured serum vitamin D and parathormone levels, and surrogate parameters for cardiovascular disease.
RESULTS: Sixty-five of 76 patients (86%) had low 25-hydroxyvitamin D levels (<30 ng ml(-1)); of those, 62 agreed to participate in the study. At baseline, only parathormone was related to vitamin D. In supplemented patients, vitamin D levels increased from 16.3 ± 6.7 to 24.3 ± 6.2 ng ml(-1) (P < 0.001), with wide variations between single patients; in the placebo group vitamin levels did not change. Seasonal factors accounted for a decrease of vitamin D levels by 8 ng ml(-1) between summer and winter. After 1 month, none of the measured parameters was influenced by vitamin substitution.
CONCLUSION: In this pilot study, most patients with PAD were vitamin D deficient. Vitamin D supplementation increased serum 25-hydroxyvitamin D without influencing endothelial function, arterial stiffness, coagulation and inflammation parameters, although the study was underpowered for definite conclusions.
H Stricker; F Tosi Bianda; S Guidicelli-Nicolosi; C Limoni; G Colucci
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-07-24
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  44     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2012-11-02     Revised Date:  2013-09-19    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
Division of Angiology, Department of Surgery, Ospedale La Carità, Via all' Ospedale, 6600 Locarno, Switzerland.
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MeSH Terms
Administration, Oral
Aged, 80 and over
Biological Markers / blood
Blood Coagulation / drug effects
Cholecalciferol / administration & dosage*,  blood
Dietary Supplements*
Double-Blind Method
Endothelium, Vascular / drug effects*,  metabolism,  physiopathology
Hemodynamics / drug effects
Inflammation Mediators / blood
Linear Models
Middle Aged
Parathyroid Hormone / blood
Peripheral Arterial Disease / blood,  drug therapy*,  physiopathology
Pilot Projects
Time Factors
Treatment Outcome
Vascular Stiffness / drug effects
Vitamin D / analogs & derivatives,  blood
Vitamin D Deficiency / blood,  drug therapy*,  physiopathology
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators; 0/PTH protein, human; 0/Parathyroid Hormone; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; 67-97-0/Cholecalciferol
Comment In:
Eur J Vasc Endovasc Surg. 2013 Aug;46(2):263   [PMID:  23683394 ]
Eur J Vasc Endovasc Surg. 2013 Aug;46(2):263   [PMID:  23702106 ]

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