Document Detail

Effect of a single bolus injection of low-dose hydrocortisone for prevention of atrial fibrillation recurrence after radiofrequency catheter ablation.
MedLine Citation:
PMID:  23006726     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The transient use of corticosteroid shortly after atrial fibrillation (AF) ablation might prevent immediate and mid-term AF recurrence; however, the effective dosage for preventing AF recurrence has not been determined. In this study, we evaluated whether low-dose hydrocortisone is effective for the prevention of AF recurrence after radiofrequency catheter ablation (RFCA).
METHODS AND RESULTS: We enrolled 89 AF patients (70 males, 55.8 ± 10.9 years) who underwent RF ablation and were treated with single bolus injection of 100mg hydrocorticosteroid (corticosteroid group). For the control group, we enrolled 120 sex- and age-matched AF patients (94 males, 55.4 ± 10.5 years). Pericarditis occurred in 3 (2.5%) and 1 (1.1%) patients in the control and corticosteroid groups, respectively. The number of patients with immediate AF recurrence (≤ 2 days) was 17 (14.5%) and 11 (12.4%) in the control and steroid groups, respectively (P=0.687). Treatment with low-dose steroid did not decrease early (3-30 days) AF recurrence (13 [11.1%] vs. 11 [12.5%], P=0.829) or late (≥ 31 days) AF recurrence after ablation (26 [22.2%] vs. 13 [14.6%], P=0.209). There was no difference in cumulative survival free of late AF recurrence between the corticosteroid and control groups (P=0.57 by log-rank test). White blood cell count, C-reactive protein concentration and maximum body temperature also were unchanged by low-dose steroid.
CONCLUSIONS: Single bolus injection of low-dose hydrocortisone after AF ablation is not effective for preventing AF recurrence during the mid-term follow-up period.
Hoyoun Won; Jong-Youn Kim; Jaemin Shim; Jae-Sun Uhm; Hui-Nam Pak; Moon-Hyoung Lee; Boyoung Joung
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-22
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  77     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-13     Revised Date:  2013-07-08    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  53-9     Citation Subset:  IM    
Cardiology Division, Department of Internal Medicine, Yonsei University Medical College, Seoul, Republic of Korea.
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MeSH Terms
Anti-Inflammatory Agents / administration & dosage*,  adverse effects
Atrial Fibrillation / prevention & control*
Catheter Ablation*
Follow-Up Studies
Hydrocortisone / administration & dosage*,  adverse effects
Middle Aged
Recurrence / prevention & control
Time Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-23-7/Hydrocortisone

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