Document Detail

Effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats.
MedLine Citation:
PMID:  23336135     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To study the effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats). METHODS: Rat tail-suspension model was used to simulate the physiological effects of microgravity and changes in pulmonary blood vessel morphology, pulmonary arterial and venous blood pressure, pulmonary vascular resistance, pulmonary vasomotoricity, as well as the regulation of pulmonary circulation by cytokines produced and released by the lung of rats were measured. RESULTS: The walls of pulmonary blood vessels of rats were thickened, and the pulmonary artery was reconstructed with increased pulmonary vascular resistance. The pulmonary blood vessels of rats became more prone to dilation as contractions increased. Rat epithelial Adrenomedulin gene transcription and protein expression were upregulated. The level of basic fibroblast growth Factor of rat was also elevated. CONCLUSION: Findings from the present study on rats revealed that the microgravity can affect pulmonary blood vessel structure, pulmonary arterial pressure, and pulmonary blood vessel self-regulation and cytokine production.
Tian Zhi Li; Ming Yuan; Zhen Hong Chen; Ying Hua Guo; Chun Yan Kang; Jing Yu Wang; Zhi Li Li; De Sheng Wang; Hui Juan Wang; Min Yuan; Chang Ting Liu
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Publication Detail:
Journal Detail:
Title:  Biomedical and environmental sciences : BES     Volume:  26     ISSN:  0895-3988     ISO Abbreviation:  Biomed. Environ. Sci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8909524     Medline TA:  Biomed Environ Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  118-127     Citation Subset:  -    
Copyright Information:
Copyright © 2013 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.
Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Beijing 100853, China.
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