| Effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats. | |
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MedLine Citation:
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PMID: 23336135 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To study the effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats). METHODS: Rat tail-suspension model was used to simulate the physiological effects of microgravity and changes in pulmonary blood vessel morphology, pulmonary arterial and venous blood pressure, pulmonary vascular resistance, pulmonary vasomotoricity, as well as the regulation of pulmonary circulation by cytokines produced and released by the lung of rats were measured. RESULTS: The walls of pulmonary blood vessels of rats were thickened, and the pulmonary artery was reconstructed with increased pulmonary vascular resistance. The pulmonary blood vessels of rats became more prone to dilation as contractions increased. Rat epithelial Adrenomedulin gene transcription and protein expression were upregulated. The level of basic fibroblast growth Factor of rat was also elevated. CONCLUSION: Findings from the present study on rats revealed that the microgravity can affect pulmonary blood vessel structure, pulmonary arterial pressure, and pulmonary blood vessel self-regulation and cytokine production. |
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Authors:
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Tian Zhi Li; Ming Yuan; Zhen Hong Chen; Ying Hua Guo; Chun Yan Kang; Jing Yu Wang; Zhi Li Li; De Sheng Wang; Hui Juan Wang; Min Yuan; Chang Ting Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Biomedical and environmental sciences : BES Volume: 26 ISSN: 0895-3988 ISO Abbreviation: Biomed. Environ. Sci. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8909524 Medline TA: Biomed Environ Sci Country: - |
Other Details:
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Languages: ENG Pagination: 118-127 Citation Subset: - |
Copyright Information:
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Copyright © 2013 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved. |
Affiliation:
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Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Beijing 100853, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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