Document Detail

The effect of sex on the minimum local analgesic concentration of ropivacaine for caudal anesthesia in anorectal surgery.
MedLine Citation:
PMID:  20304981     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Caudal anesthesia is routinely used in our hospital for most of ambulatory anorectal surgery; patients need to recover as quickly as possible. The dose of local anesthetic may be different for male and female patients. We designed this study to investigate the effect of sex on the minimum local anesthetic concentration (MLAC) of ropivacaine for caudal anesthesia. METHODS: In this double-blind, prospective study, we enrolled 70 ASA physical status I patients (35 male and 35 female) who were scheduled for anorectal surgery under caudal anesthesia, and allocated them to 2 study groups according to their gender. Each participant received a single injection of 20 mL ropivacaine through a caudal catheter. Using Dixon's up-and-down sequential allocation, the first participant received 0.2% and subsequent concentrations were determined by the analgesic response of the previous patients to the initial skin incision and laxity of the anal sphincter. The concentration change was 0.025%. The up-and-down sequences were analyzed using the Dixon and Massey method to quantify the caudal analgesic block effective concentrations in 50% of patients. RESULTS: The MLAC of ropivacaine for caudal analgesia was 0.296% (95% confidence interval, 0.286%-0.307%) in male patients and 0.389% (95% confidence interval, 0.372%-0.407%) in female patients (P < 0.01). CONCLUSIONS: We conclude that the ropivacaine MLAC for caudal anesthesia in female patients is 31% larger than in male patients.
Yuhong Li; Yujie Zhou; Hanjian Chen; Zhiying Feng
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-19
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  110     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-05-13     Revised Date:  2010-05-28    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1490-3     Citation Subset:  AIM; IM    
Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
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MeSH Terms
Amides / administration & dosage*
Anal Canal / surgery*
Analgesics, Opioid / administration & dosage,  therapeutic use
Anesthesia, Caudal*
Anesthetics, Local / administration & dosage*
Endpoint Determination
Hemodynamics / drug effects
Hemorrhoids / surgery
Middle Aged
Pain Measurement
Pain, Postoperative / drug therapy
Preanesthetic Medication
Rectal Fistula / surgery
Rectum / surgery*
Sex Characteristics
Reg. No./Substance:
0/Amides; 0/Analgesics, Opioid; 0/Anesthetics, Local; 84057-95-4/ropivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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