| The effect of sex on the minimum local analgesic concentration of ropivacaine for caudal anesthesia in anorectal surgery. | |
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MedLine Citation:
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PMID: 20304981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Caudal anesthesia is routinely used in our hospital for most of ambulatory anorectal surgery; patients need to recover as quickly as possible. The dose of local anesthetic may be different for male and female patients. We designed this study to investigate the effect of sex on the minimum local anesthetic concentration (MLAC) of ropivacaine for caudal anesthesia. METHODS: In this double-blind, prospective study, we enrolled 70 ASA physical status I patients (35 male and 35 female) who were scheduled for anorectal surgery under caudal anesthesia, and allocated them to 2 study groups according to their gender. Each participant received a single injection of 20 mL ropivacaine through a caudal catheter. Using Dixon's up-and-down sequential allocation, the first participant received 0.2% and subsequent concentrations were determined by the analgesic response of the previous patients to the initial skin incision and laxity of the anal sphincter. The concentration change was 0.025%. The up-and-down sequences were analyzed using the Dixon and Massey method to quantify the caudal analgesic block effective concentrations in 50% of patients. RESULTS: The MLAC of ropivacaine for caudal analgesia was 0.296% (95% confidence interval, 0.286%-0.307%) in male patients and 0.389% (95% confidence interval, 0.372%-0.407%) in female patients (P < 0.01). CONCLUSIONS: We conclude that the ropivacaine MLAC for caudal anesthesia in female patients is 31% larger than in male patients. |
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Authors:
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Yuhong Li; Yujie Zhou; Hanjian Chen; Zhiying Feng |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-19 |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 110 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-05-13 Revised Date: 2010-05-28 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 1490-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amides / administration & dosage* Anal Canal / surgery* Analgesics, Opioid / administration & dosage, therapeutic use Anesthesia, Caudal* Anesthetics, Local / administration & dosage* Endpoint Determination Female Hemodynamics / drug effects Hemorrhoids / surgery Humans Male Middle Aged Pain Measurement Pain, Postoperative / drug therapy Preanesthetic Medication Rectal Fistula / surgery Rectum / surgery* Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Analgesics, Opioid; 0/Anesthetics, Local; 84057-95-4/ropivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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