Document Detail


The effect of sea buckthorn supplement on oral health, inflammation, and DNA damage in hemodialysis patients: a double-blinded, randomized crossover study.
MedLine Citation:
PMID:  23131570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Chronic kidney disease is associated with inflammation, oxidative stress, malnutrition, poor oral health, and mouth dryness. The objective of this study was to evaluate effects of sea buckthorn oil (SBO) extract, which is rich in vitamins, phytochemicals, and polyunsaturated fatty acids, on oxidative stress, saliva production, and inflammation in hemodialysis patients.
DESIGN SETTING AND SUBJECTS: This was a randomized, double-blinded, and placebo-controlled crossover study (2 × 8 weeks, 4-week washout). The study subjects were hemodialysis patients (n = 45) recruited from the Department of Renal Medicine at Karolinska University Hospital in Stockholm.
INTERVENTION AND MAIN OUTCOME MEASURES: The patients received 4 capsules per day, each containing 500 mg of SBO or placebo, for 8 weeks. They were then crossed over to the other treatment after a 4-week washout period. Salivary gland biopsies, saliva, and blood samples were collected before and after each treatment period. Main outcomes were DNA breaks and oxidative DNA lesions in minor accessory salivary glands, salivary flow rates, and inflammation markers in blood (high-sensitivity C-reactive protein, antitrypsin, orosomucoid in plasma, leukocytes in blood). Blood markers including creatinine, urea in plasma, and hemoglobin in blood were investigated.
RESULTS: The results showed no significant changes in DNA breaks, oxidative DNA lesions, salivary flow rates, or inflammation after SBO supplementation. However, plasma levels of phosphate and sodium increased and plasma levels of iron decreased.
CONCLUSION: In conclusion, SBO supplementation as performed in this study did not protect against oxidative stress, nor improve oral health or inflammation status in hemodialysis patients.
Authors:
Ylva Rodhe; Therese Woodhill; Royne Thorman; Lennart Möller; Britta Hylander
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-11-04
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  23     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-24     Completed Date:  2014-01-03     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  172-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
C-Reactive Protein / analysis,  metabolism
Creatinine / blood
Cross-Over Studies
DNA Damage / drug effects*
Dietary Supplements*
Double-Blind Method
Female
Hippophae / chemistry*
Humans
Inflammation / drug therapy*
Iron / blood
Male
Middle Aged
Oral Health*
Orosomucoid / analysis,  metabolism
Oxidative Stress / drug effects
Phosphates / blood
Plant Oils / administration & dosage
Renal Dialysis / adverse effects*
Saliva / drug effects,  metabolism
Sodium / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Orosomucoid; 0/Phosphates; 0/Plant Oils; 9007-41-4/C-Reactive Protein; 9NEZ333N27/Sodium; AYI8EX34EU/Creatinine; E1UOL152H7/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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