Document Detail


Effect of San'ao Decoction () on the airway inflammation and hyperresponsiveness in a murine model of lipopolysaccharide-enhanced asthma.
MedLine Citation:
PMID:  21725880     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: San'ao Decoction (, SAD), as a representative Chinese medicine (CM) formula, was chosen to evaluate the effect of airway inflammation and hyperresponsiveness on the lipopolysaccharide (LPS) enhanced asthma model.
METHODS: The asthma model was reproduced in the Balb/C mice sensitized by ovalbumin (OVA), challenged by OVA and LPS. After Balb/C mice's administration of a dose (0.0024 g/kg) of dexamethasone acetate, and three doses (2.2 g/kg, 4.4 g/kg and 8.8 g/kg) of SAD, airway inflammation and responsiveness were observed. The airway inflammation was detected by counting bronchoalveolar lavage fluid (BALF) cells and lung histopathology. Also, differential expressions of interferon-r (IFN-γ), interleukin-4 (IL-4), and IL-5 in the supernatants of BALF were examined. The changes in airway responsiveness indicated by lung resistance (R(L)) and stimulated by acetylcholine (Ach) were determined.
RESULTS: Small-dose SAD hardly inhibit airway inflammation or hyperresponsiveness in the LPS-enhanced asthma, while medium-dose and high-dose SAD significantly inhibited the airway hyperresponsiveness, and to some extent, reduced airway inflammation. Meanwhile, the small-dose, medium-dose, and high-dose SAD promoted Th1-type cytokines (IFN-γ) and reduced Th2-type cytokines (IL-4, IL-5) to different extents, which led to a Th1/Th2 balance.
CONCLUSION: SAD has a good therapeutic effect on airway hyperresponsiveness in the LPS-enhanced asthma model, but its definite influence on airway inflammation is not remarkable.
Authors:
Peng-Cheng Gu; Xin-Sheng Fan; Chen-Xue Jiang; Hui-Qin Xu; Jing-Hua Yu; Yu-Ping Tang
Publication Detail:
Type:  Journal Article     Date:  2011-07-03
Journal Detail:
Title:  Chinese journal of integrative medicine     Volume:  17     ISSN:  1672-0415     ISO Abbreviation:  Chin J Integr Med     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181180     Medline TA:  Chin J Integr Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  537-41     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Nanjing University of Chinese Medicine, Nanjing, 210029, China.
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