Document Detail

Effect of SP3 silencing on cytokeratin expression pattern in HPV-positive cells.
MedLine Citation:
PMID:  19309563     Owner:  NLM     Status:  MEDLINE    
In an attempt to understand the molecular factors underlying squamous cell carcinogenesis in HPV-infected oral and cervical tissues, we examined the Sp3-dependent cytokeratin expression in HPV-positive CaSki cells. Two sets of cytokeratins were examined: the simple epithelial CK 7, 8, 18, 19, and 20, which are generally expressed in simple epithelia and CK4, 10, 13, and 17, which are expressed in squamous epithelia. Two additional CK pairs, i.e. CK6/CK16 and CK4/CK13 were analyzed as controls of the proliferation/differentiation cell status, respectively. We report that Sp3 gene silencing specifically hits CK18 and CK19, which are markers of oral and cervical squamous tumors. These data may be of help in immunopathological definition of squamous carcinogenesis.
A Lucchese; R Serpico
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  22     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2009 Jan-Mar
Date Detail:
Created Date:  2009-03-24     Completed Date:  2009-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Department of Odontostomatology, Orthodontics and Surgical Disciplines, University of Naples (SUN), Naples, Italy.
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MeSH Terms
Carcinoma, Squamous Cell / etiology*,  virology
Cell Line, Tumor
Gene Silencing
Human papillomavirus 16 / pathogenicity*
Keratins / analysis*
Sp3 Transcription Factor / genetics,  physiology*
Reg. No./Substance:
0/SP3 protein, human; 148710-94-5/Sp3 Transcription Factor; 68238-35-7/Keratins

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