Document Detail

The Effect of Resistance Exercise on p53, Caspase-9, and Caspase-3 in Trained and Untrained Men.
MedLine Citation:
PMID:  22446679     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT:: Sharafi, H, and Rahimi, R. The effect of resistance exercise on p53, caspase-9, and caspase-3 in trained and untrained men. J Strength Cond Res 26(4): 1142-1148, 2012-Apoptosis is a programmed cell death that has been demonstrated in human and animal studies and plays an essential role to remove injured cells after acute strenuous exercise. Protein p53 plays important roles in regulating apoptosis via mitochondrial pathway. Therefore, the aims of this study were to determine the effects of acute resistance exercise (RE) on serum p53, caspase-9, and caspase-3, markers of apoptosis, and whether resistance training status influences the magnitude of the RE-induced apoptosis. Nine resistance-trained (RT) (age, 22.37 ± 1.99 years; height, 174 ± 5.04 cm; body weight, 71.32 ± 5.57 kg; and body mass index [BMI] 23.58 ± 2.05 kg·m) and 9 untrained (UT) college-age men (age, 22.25 ± 2.13 years; height, 171 ± 3.4 cm; body weight, 68.45 ± 3.23 kg; and BMI, 23.41 ± 1.08 kg·m) volunteered to participate in this study. Resistance-trained and UT men completed an RE bout consisting of 4 sets of 6 exercise at 80% of 1 repetition maximum until failure. Serum levels of p53, caspase-9, and caspase-3 were examined at preexercise (pre), immediately post (IP), 3 hours post (3 hours post), and 24 hours post RE (24 hours post). In UT, serum levels of p53, caspase-9, and caspase-3 were significantly increased at IP compared with RT. However, plasma insulin-like growth factor 1 level was higher for RT compared with UT at IP. Collectively, our data suggest the role of p53 in regulating apoptosis through mitochondrial pathway as measured by caspase-9 and caspase-3 after acute RE in UT. Our results also revealed that regular RT alters apoptosis biomarkers, especially the intrinsic pathway of apoptosis.
Hossein Sharafi; Rahman Rahimi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of strength and conditioning research / National Strength & Conditioning Association     Volume:  26     ISSN:  1533-4287     ISO Abbreviation:  J Strength Cond Res     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9415084     Medline TA:  J Strength Cond Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1142-8     Citation Subset:  IM    
1Department of Physical Education & Sport Sciences, Mahabad Branch, Islamic Azad University, Mahabad, Iran 2Department of Physical Education and Sport Sciences, University of Kurdistan, Sanandaj, Iran.
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