| The Effect of Recombinant Stromal Cell-Derived Factor-1 Treatment on Hypoxic-Ischemic Brain Injury in Neonatal Mice. | |
MedLine Citation:
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PMID: 23044817 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background Stromal cell-derived factor-1 (SDF-1) plays a critical role in adult brain injury repair including neurogenesis and vasculogenesis. However, the effects of recombinant SDF-1(rSDF-1) treatment on hypoxic-ischemic (HI) brain injury in neonatal mice are not clear.Materials and Methods Seven-day-old (P7) C57BL/6J mice were divided into sham group, control group, and rSDF-1 group. Mice brains were collected to determine histopathological damage and the expression level of SDF-1, caspase-3, and Ki67 on P8, P10, P14, and P21. Passive avoidance and elevated plus-maze tests were also assessed on P20 and P21.Results Compared with control group, rSDF-1 treatment increased the weight ratio of left and right brain hemisphere (p < 0.05), reduced the number of electric foot shocks (p < 0.05) and the percentage of time spent in the open arms (p < 0.05), meanwhile, increased the retention latency (p < 0.05) and the percentage of time spent in the enclosed arms (p < 0.05) on P20 and P21. High expression of Ki67 and low expression of caspase-3 were also observed.Discussion This study showed that rSDF-1 treatment effectively alleviated brain injury shown by reducing in caspase-3 expression and increasing in Ki67 expression. Moreover, rSDF-1 treatment significantly improved behavioral performances in juvenile mice after HI. |
Authors:
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Weiwei Zhu; Xiaoli Ma; Feng Li; Jun Wang; Lichun Yu; Mi Xu; Aihua Ma; Aili Guo; Nan Zhang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-8 |
Journal Detail:
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Title: Neuropediatrics Volume: - ISSN: 1439-1899 ISO Abbreviation: Neuropediatrics Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8101187 Medline TA: Neuropediatrics Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. |
Affiliation:
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Department of Pediatrics, Jinan Central Hospital affiliated to Shandong University, Jinan, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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