| Effect of Ramadan fasting on glycaemic control in patients with Type 2 diabetes. | |
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MedLine Citation:
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PMID: 21986487 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Although Muslim patients with Type 2 diabetes may be exempt from fasting during Ramadan for medical reasons, a high proportion of them fast. Aim: To investigate the association between Ramadan fasting and glycaemic control in patients with Type 2 diabetes. Subjects and Methods: A prospective cohort clinical trial was designed. 88 patients with Type 2 diabetes (45 male, 43 female, age: 51 ± 10 yrs) who opted to fast for at least 10 days during the month of Ramadan were recruited. Fasting blood samples were taken at the beginning and end of Ramadan, and one month after Ramadan, to assess fasting blood glucose (FBG), fasting insulin, full blood count, haemoglobin A1C (HbA1c) and fasting lipid profile. Insulin resistance was estimated using the homeostatic model assessment (HOMA-IR). Anthropometrics and blood pressure were also measured. Results: There was a significant deterioration in FBG and HbA1c (p=0.002 and p=<0.001 respectively) and significant improvements in HDL and LDL cholesterol and Body Mass Index after Ramadan (p<0.001). Interestingly, HbA1c showed a reduction one month after Ramadan (9.4 ± 2% at the end of Ramadan vs. 8.4 ± 2.5% one month after Ramadan; p<0.001). Conclusion: Results from this study showed that fasting during Ramadan deteriorated the glycaemic control in Type 2 diabetes patients. This was more evident in patients using oral hypoglycaemic medication than diet-controlled patients. However, Ramadan fasting had small positive effects on lipid profile and body weight. |
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Authors:
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Abdolreza Norouzy; Seyed Mohammad Reza Mohajeri; Sara Shakeri; Farnoosh Yari; Maryam Sabery; Elena Philippou; A-Reza Varasteh; Mohsen Nematy |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-6 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Nutrition, School of Medicine, Mashad University of Medical Sciences, 91779-48564, Mashad, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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