Document Detail

The effect of pulmonary hypertension on left ventricular diastolic function in chronic obstructive lung disease: a tissue Doppler imaging and right cardiac catheterization study.
MedLine Citation:
PMID:  20589939     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulmonary hypertension (PH) caused by chronic obstructive lung disease (COLD) essentially involves the right heart. Also left ventricular (LV) systolic and diastolic functions may be affected.
OBJECTIVES: The aim of this study was to investigate the effect of on LV diastolic function in patients with COLD.
METHODS: A total of 47 patients with COLD and 20 controls were included in this study. All patients underwent Doppler echocardiography, tissue Doppler imaging examinations and right cardiac catheterization. The patients were divided into 2 subgroups according to mean pulmonary arterial pressure (mPAP): patients without PH (group1, n = 25) and with PH (group 2, n = 22). The following measurements were taken: peak velocity of early diastolic filling (E), peak late filling with atrial contraction (A), E/A ratio, deceleration time (DT) of E, isovolumic relaxation time (IVRT), early (Em) and late (Am) diastolic mitral lateral annulus velocity.
RESULTS: Mitral E/A < 1 and Em < 8 cm/sec were higher in group 2 than in group 1 and the control group. There were significant correlations between mPAP and both mitral E/A (r:- 0.60) and Em (r:- 0.45). In multivariate model, mPAP was not found to be significant on mitral E/A ratio < 1, but there was a significant effect on mitral Em < 8 cm/sec (odds ratio [OR]:1.14, P < 0.05).
CONCLUSION: This study shows that LV diastolic dysfunction in COLD is closely correlated to PH levels. Although increased mPAP may affect the mitral E/A ratio, it seems to have no effect on mitral E/A < 1, whereas it has an independent effect on Em < 8 cm/sec.
Mahmut Acikel; Nuri Kose; Alpay Aribas; Hasan Kaynar; Serdar Sevimli; Yekta Gurlertop; M Kemal Erol
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  33     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E13-8     Citation Subset:  IM    
Department of Cardiology, Ataturk University Faculty of Medicine, Erzurum, Turkey.
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MeSH Terms
Blood Pressure
Case-Control Studies
Chi-Square Distribution
Echocardiography, Doppler*
Echocardiography, Doppler, Pulsed
Heart Catheterization*
Hypertension, Pulmonary / etiology*,  physiopathology,  ultrasonography
Logistic Models
Middle Aged
Mitral Valve / physiopathology,  ultrasonography
Odds Ratio
Predictive Value of Tests
Pulmonary Disease, Chronic Obstructive / complications*,  physiopathology,  ultrasonography
Ventricular Dysfunction, Left / etiology*,  physiopathology,  ultrasonography
Ventricular Function, Left*

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