| The effect of pulmonary hypertension on left ventricular diastolic function in chronic obstructive lung disease: a tissue Doppler imaging and right cardiac catheterization study. | |
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MedLine Citation:
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PMID: 20589939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pulmonary hypertension (PH) caused by chronic obstructive lung disease (COLD) essentially involves the right heart. Also left ventricular (LV) systolic and diastolic functions may be affected. OBJECTIVES: The aim of this study was to investigate the effect of on LV diastolic function in patients with COLD. METHODS: A total of 47 patients with COLD and 20 controls were included in this study. All patients underwent Doppler echocardiography, tissue Doppler imaging examinations and right cardiac catheterization. The patients were divided into 2 subgroups according to mean pulmonary arterial pressure (mPAP): patients without PH (group1, n = 25) and with PH (group 2, n = 22). The following measurements were taken: peak velocity of early diastolic filling (E), peak late filling with atrial contraction (A), E/A ratio, deceleration time (DT) of E, isovolumic relaxation time (IVRT), early (Em) and late (Am) diastolic mitral lateral annulus velocity. RESULTS: Mitral E/A < 1 and Em < 8 cm/sec were higher in group 2 than in group 1 and the control group. There were significant correlations between mPAP and both mitral E/A (r:- 0.60) and Em (r:- 0.45). In multivariate model, mPAP was not found to be significant on mitral E/A ratio < 1, but there was a significant effect on mitral Em < 8 cm/sec (odds ratio [OR]:1.14, P < 0.05). CONCLUSION: This study shows that LV diastolic dysfunction in COLD is closely correlated to PH levels. Although increased mPAP may affect the mitral E/A ratio, it seems to have no effect on mitral E/A < 1, whereas it has an independent effect on Em < 8 cm/sec. |
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Authors:
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Mahmut Acikel; Nuri Kose; Alpay Aribas; Hasan Kaynar; Serdar Sevimli; Yekta Gurlertop; M Kemal Erol |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 33 ISSN: 1932-8737 ISO Abbreviation: Clin Cardiol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-24 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: E13-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Ataturk University Faculty of Medicine, Erzurum, Turkey. macikel@atauni.edu.tr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure Case-Control Studies Chi-Square Distribution Diastole Echocardiography, Doppler* Echocardiography, Doppler, Pulsed Female Heart Catheterization* Humans Hypertension, Pulmonary / etiology*, physiopathology, ultrasonography Logistic Models Male Middle Aged Mitral Valve / physiopathology, ultrasonography Odds Ratio Predictive Value of Tests Pulmonary Disease, Chronic Obstructive / complications*, physiopathology, ultrasonography Turkey Ventricular Dysfunction, Left / etiology*, physiopathology, ultrasonography Ventricular Function, Left* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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