Document Detail


Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats.
MedLine Citation:
PMID:  20178824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM OF THE STUDY: The present study was designed to investigate the effect of bark of Pterocarpus santalinus, an ethnomedicinal plant, on blood glucose, plasma insulin, serum lipids and the activities of hepatic glucose metabolizing enzymes in streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Streptozotocin-induced diabetic rats were treated (acute/short-term and long-term) with ethyl acetate:methanol fractions of ethanolic extract of the bark of P. santalinus. Fasting blood glucose, HbA(1C), plasma insulin and protein were estimated before and after the treatment, along with hepatic glycogen, and activities of hexokinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase and glucose-6-phosphate dehydrogenase. Further anti-hyperlipidemic activity was studied by measuring the levels of serum lipids and lipoproteins. RESULTS: Phytochemical analysis of active fraction showed the presence of flavonoids, glycosides and phenols. Biological testing of the active fraction demonstrated a significant antidiabetic activity by reducing the elevated blood glucose levels and glycosylated hemoglobin, improving hyperlipidemia and restoring the insulin levels in treated experimental induced diabetic rats. Further elucidation of mechanism of action showed improvement in the hepatic carbohydrate metabolizing enzymes after the treatment. Our present investigation suggests that active fraction of ethanolic extract of bark of P. santalinus decreases streptozotocin induced hyperglycemia by increasing glycolysis and decreasing gluconeogenesis.
Authors:
Vinay Kumar Kondeti; Kameswara Rao Badri; Dilip Rajasekhar Maddirala; Sampath Kumar Mekala Thur; Shaik Sameena Fatima; Ramesh Babu Kasetti; Chippada Appa Rao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-21
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1281-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biochemistry, Sri Venkateswara University, Tirupathi, Andhra Pradesh, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / analysis
Chemical Fractionation
Diabetes Mellitus, Experimental / blood,  complications,  drug therapy*
Flavonoids / analysis
Fructose-Bisphosphatase / metabolism
Glucose-6-Phosphatase / metabolism
Glycosides / analysis
Hyperlipidemias / blood,  drug therapy*,  etiology
Hypoglycemic Agents / chemistry,  pharmacology*
Insulin / blood
Lipids / blood
Liver / drug effects*,  enzymology
Liver Glycogen / metabolism
Male
Phenols / analysis
Plant Extracts / chemistry,  pharmacology*
Pterocarpus / chemistry*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Flavonoids; 0/Glycosides; 0/Hypoglycemic Agents; 0/Lipids; 0/Liver Glycogen; 0/Phenols; 0/Plant Extracts; 0/Pterocarpus santalinus extract; 11061-68-0/Insulin; EC 3.1.3.11/Fructose-Bisphosphatase; EC 3.1.3.9/Glucose-6-Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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