Document Detail


Effect of propofol on breathing stability in adult ICU patients with brain damage.
MedLine Citation:
PMID:  20298815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to investigate Propofol's effect on breathing stability in brain damage patients, as quantified by the Loop Gain (LG) of the respiratory system (breathing stability increases with decreasing LG). In 11 stable brain damage patients full polysomnography was performed before, during and after propofol sedation, titrated to achieve stage 2 or slow wave sleep. During each period, patients were ventilated with proportional assist ventilation and the % assist was increased in steps, until either periodic breathing (PB) occurred or the highest assist (95%) was achieved. The tidal volume amplification factor (VT(AF)) at the highest assist level reached just before PB occurred was used to calculate LG (LG=1/VT(AF)). In all but one patient, PB was observed. With propofol, the assist level at which PB occurred (73 + or - 19%) was significantly higher, than that before (43 + or - 35%) and after propofol sedation (49 + or - 29%). As a result, with propofol LG (0.49 + or - 0.2) was significantly lower than that before (0.74 + or - 0.2) and after propofol sedation (0.69 + or - 0.2) (p<0.05). We conclude that Propofol decreases LG. Therefore it exerts an overall stabilizing effect on control of breathing.
Authors:
Maria Klimathianaki; Eumorfia Kondili; Christina Alexopoulou; George Prinianakis; Dimitris Georgopoulos
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2010-03-16
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  171     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  232-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Intensive Care Medicine Department, University Hospital of Heraklion, Medical School, University of Crete, Heraklion, Crete 77 10, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Brain Damage, Chronic / etiology,  physiopathology*
Brain Injuries / complications,  physiopathology
Female
Humans
Hypnotics and Sedatives / pharmacology*
Intensive Care Units
Male
Middle Aged
Polysomnography
Propofol / pharmacology*
Respiration / drug effects*
Ventilators, Mechanical
Young Adult
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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