Document Detail

Effect of processing route on the surface properties of amorphous indomethacin measured by inverse gas chromatography.
MedLine Citation:
PMID:  23135965     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the effect of processing route (i.e., quench cooling and ball milling) on the surface energy heterogeneity and surface chemistry of indomethacin (IMC). Recently developed inverse gas chromatography (IGC) methodology at finite concentrations was employed to determine the surface energy distributions of crystalline, quench cooled and milled IMC samples. Surface properties of crystalline and processed IMC were measurably different as determined by the IGC and other conventional characterization techniques: differential scanning calorimetry and powder X-ray diffraction. Quench cooled IMC was in fully amorphous form. Milled IMC showed no amorphous character by calorimetric or X-ray diffraction studies. It was demonstrated that both processed IMC samples were energetically more active than the crystalline IMC. In particular, milled IMC exhibited a relatively higher dispersive surface energy and higher surface basicity (electron donor capability). This may be attributed to the creation of surface defect sites or exposure of higher energy crystal facets during the milling process. This study confirms that processing route has notable influence on the surface energy distribution and surface acid-base character. IGC was demonstrated as a powerful technique for investigating surface properties of real-world, heterogeneous pharmaceutical materials.
D J Burnett; J Khoo; M Naderi; J Y Y Heng; G D Wang; F Thielmann
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Publication Detail:
Type:  Journal Article     Date:  2012-11-08
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  13     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-04     Completed Date:  2013-05-15     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1511-7     Citation Subset:  IM    
Surface Measurement Systems, Ltd, 2125 28th Street SW, Suite 1, Allentown, Pennsylvania 18103, USA.
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MeSH Terms
Calorimetry, Differential Scanning / methods
Chemistry, Pharmaceutical / methods
Chromatography, Gas / methods
Crystallization / methods
Indomethacin / chemistry*
Surface Properties
Technology, Pharmaceutical / methods*
X-Ray Diffraction / methods
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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