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Effect Of Probiotic Or Prebiotic Supplementation To Antibiotic Therapy In The Small Inestinal Bacterial Overgrowth: A Comparative Evaluation.
MedLine Citation:
PMID:  23244247     Owner:  NLM     Status:  Publisher    
Bacterial intestinal overgrowth syndrome (SIBO) treatment is based on antibiotics. Probiotics have been shown to give similar results, whilst no study is available about prebiotics. This study evaluated the addition of probiotics or prebiotics to antibiotics on SIBO symptoms in a 6-month follow-up. We enrolled 40 patients (14 males and 26 females) reporting abdominal compliant without gastrointestinal diseases/alarm symptoms. SIBO was diagnosed by the agreement of lactulose and glucose breath tests. Patients were randomly divided into two groups homogeneous for sex and age: group 1 received Rifaximin 400 mg/day for 7 days/month followed by Lactobacillus casei for 7 days more and group 2 antibiotic followed by short chain fructo-oligosaccharides. All patients recorded a questionnaire for subjective symptom evaluation according to Rome III criteria and Bristol scale for stool characters before the study and after 6 months. Statistics: Student's t and Fisher's exact tests. In group 1, a significant improvement was obtained in 5 out 6 symptoms, whilst in group 2 in 4 out 6 symptoms (nausea and number of bowel movements failed to improve). Despite we observed a trend of probiotics to be more effective than prebiotics, the difference in the percentage of improved symptoms was not significant (83,3% vs 66.6%; p= 0.57). Our preliminary data show a good outcome with sequential antibiotic-probiotic/prebiotic administration in patients with SIBO.
Rosa Rosania; Floriana Giorgio; Mariabeatrice Principi; Annacinzia Amoruso; Rosa Monno; Alfredo Di Leo; Enzo Ierardi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-10
Journal Detail:
Title:  Current clinical pharmacology     Volume:  -     ISSN:  2212-3938     ISO Abbreviation:  Curr Clin Pharmacol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101273158     Medline TA:  Curr Clin Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Gastroenterology Section, Department of Medical Sciences University of Foggia, AOU Ospedali Riuniti Viale Pinto 71100 Foggia, Italy
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