Document Detail


Effect of prematurity on protein glycosylation in the newborn.
MedLine Citation:
PMID:  21486378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Glycohemoglobins (GHb) are the products of irreversible non-enzymatic reactions between glucose and the hemoglobin molecule. Glycosylation of proteins in general can modify protein structure and alter catalytic properties, thereby causing cellular dysfunction. The aim of the present study was to test the hypothesis that protein glycosylation levels in premature infants are elevated compared with full-term infants (neonates). Blood GHb levels in pre-term and full-term infants were studied, and the in vitro glycosylation of erythrocytes obtained from both pre-term and full-term infants was assessed.
METHODS: Cord-blood from 31 pre-term and 11 full-term infants was collected and GHb levels were determined using affinity columns. Erythrocytes from the cord blood of 17 additional infants (eight pre-term, ≤ 36 weeks gestation, and nine full-term, ≥ 37 weeks gestation) were obtained and incubated for 24 h in a high-glucose medium. Baseline and post-incubation GHb levels were calculated to determine the in vitro susceptibility of pre-term versus full-term infants to glycosylation.
RESULTS: Blood GHb levels were significantly higher (P < 0.01) in full-term compared with pre-term infants. The percent increase in GHb formation in vitro was similar between the erythrocytes of full-term and those of pre-term infants.
CONCLUSION: Contrary to the original hypothesis, the erythrocytes of pre-term infants do not show increased glycosylation of proteins when compared with those of full-term infants.
Authors:
Gerald B Whitton; Ramasubbareddy Dhanireddy; Sushil K Jain
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  53     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-19     Completed Date:  2012-03-20     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  480-2     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Pediatrics International © 2011 Japan Pediatric Society.
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MeSH Terms
Descriptor/Qualifier:
Erythrocytes / metabolism
Fetal Blood / metabolism
Glycosylation
Hemoglobin A, Glycosylated / metabolism*
Humans
Infant, Newborn
Infant, Premature / blood*
Grant Support
ID/Acronym/Agency:
R01 DK072433/DK/NIDDK NIH HHS; R01 DK072433/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobin A, Glycosylated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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