Document Detail

The Effect of Pregnancy on Production of Maternal Endogenous Hematopoietic Stem Cells.
MedLine Citation:
PMID:  19122820     Owner:  NLM     Status:  Publisher    
Fetal microchimerism refers to the presence of fetal cells in maternal blood and tissues during pregnancy. This microchimerism may result from trafficking of fetal and maternal blood across the placenta during pregnancy. Physiological changes in the maternal blood cellular milieu are also recognized during pregnancy and in the early post partum period. Earlier studies showed that maternal blood contains CD34(+) hematopoietic stem cells (HSCs) that bear paternal genetic markers or male phenotype, suggesting that these cells circulated to the mother from male fetuses during pregnancy. Other studies showed that these maternal HSCs have significantly lower expansion potential than their fetal counterparts. We have recently shown increased percentages of CD34(+) HSCs in peripheral blood of pregnant and parous women. Herein, we hypothesize that pregnancy stimulates the production of endogenous CD34(+) HSCs of maternal origin, a phenomenon which potentially could favor post partum regenerative capacity.
Nagwa S El-Badri; Maureen Groer
Publication Detail:
Journal Detail:
Title:  Bioscience hypotheses     Volume:  1     ISSN:  1876-746X     ISO Abbreviation:  -     Publication Date:  2008  
Date Detail:
Created Date:  2009-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101480360     Medline TA:  Biosci Hypotheses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  100-102     Citation Subset:  -    
Department of Neurosurgery, College of Medicine, University of South Florida.
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Grant Support
R01 NR005000-05//NINR NIH HHS

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