Document Detail


Effect of pregnancy on postural tachycardia syndrome.
MedLine Citation:
PMID:  20516426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To compare the clinical presentation, autonomic dysfunction, and pregnancy outcomes in parous and nulliparous women with postural tachycardia syndrome (POTS) and in women with POTS before and after pregnancy.
PATIENTS AND METHODS: This study consists of women who had at least 1 pregnancy during which time they met criteria for POTS between May 1993 and July 2009. All patients underwent standard autonomic testing. POTS was defined as a heart rate (HR) increase of greater than 30 beats/min on head-up tilt (HUT) with symptoms of orthostatic intolerance. Patients' charts were reviewed retrospectively to determine pregnancy outcomes.
RESULTS: Clinical characteristics related to POTS did not differ between parous and nulliparous women except for disease duration (parous, 3.7+/-2.6; nulliparous, 2.1+/-2.2; P<.001). Autonomic dysfunction did not differ between groups (change in HR on HUT: parous, 42.6+/-12.0 beats/min; nulliparous, 41.3+/-10.6 beats/min; P=.39). Of 116 total pregnancies, adverse pregnancy outcomes were reported in 9% and maternal complications in 1%. No complication was related to POTS. There was a trend toward modest improvement in autonomic dysfunction before and after pregnancy (change in HR on HUT: before pregnancy, 38.1+/-22.7 beats/min; after pregnancy, 21.9+/-14.9 beats/min; P=.07).
CONCLUSION: The long-term impact of pregnancy on POTS does not appear to be clinically important. However, there does appear to be a trend toward improvement in the short-term postpartum period. Adverse pregnancy events were similar to those seen in the general public and do not present a barrier to women with POTS who want to have children.
Authors:
Kurt Kimpinski; Valeria Iodice; Paola Sandroni; Phillip A Low
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-06-01
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  85     ISSN:  1942-5546     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-07-16     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  639-44     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology
Adult
Analysis of Variance
Female
Heart Rate
Humans
Maternal Age
Minnesota / epidemiology
Parity*
Postural Orthostatic Tachycardia Syndrome / complications*,  diagnosis,  epidemiology
Pregnancy
Pregnancy Complications / diagnosis,  epidemiology,  etiology*
Pregnancy Outcome / epidemiology*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Retrospective Studies
Risk Factors
Severity of Illness Index
Statistics, Nonparametric
Tilt-Table Test
Grant Support
ID/Acronym/Agency:
NS22352/NS/NINDS NIH HHS; NS32352/NS/NINDS NIH HHS; NS43364/NS/NINDS NIH HHS; NS44233/NS/NINDS NIH HHS; UL1 RR24150/RR/NCRR NIH HHS
Comments/Corrections

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