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Effect of Pre-Bypass Methylprednisolone on Post-Operative Renal Function Following Correction of Atrial Septal Defect under Cardiopulmonary Bypass.
MedLine Citation:
PMID:  22314458     Owner:  NLM     Status:  In-Data-Review    
Conventional open heart surgery with cardiopulmonary bypass (CPB) are associated with transient post-operative renal dysfunction which is caused by systemic inflammatory response induced by CPB. Corticosteroids are administered to attenuate the systemic inflammatory response. The purpose of this study was to compare the effects of pre-bypass and post-bypass methylprednisolone on postoperative renal function after correction of ASD under CPB. Forty (40) patients were selected in the University cardiac centre of BSMMU undergoing ASD correction under CPB. Patients were randomized into two group to receive pre-bypass (Group A) or post-bypass (Group B) methylprednisolone 30mg/kg. Markers of glomerular function (BUN, serum creatinine, creatinine clearance) and damage (micro-albuminuria) and tubular function (glucosuria) were evaluated 24 hours after operation. Transient impairment of glomerular and tubular function of kidney was observed in patients those received post-bypass metylprednisolone (Group B) while Group A patients shown no significant difference between baseline and post-operative renal function. Use of pre-bypass metylprednisolone has a protective effect on post-operative renal function after correction of ASD under CPB.
S Dhar; Z Rahman; K Hasan; M F Hoque; A Sultana
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mymensingh medical journal : MMJ     Volume:  21     ISSN:  1022-4742     ISO Abbreviation:  Mymensingh Med J     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9601799     Medline TA:  Mymensingh Med J     Country:  Bangladesh    
Other Details:
Languages:  eng     Pagination:  72-9     Citation Subset:  IM    
Dr Satyajit Dhar, Junior Consultant (Anesthesiology), Upazila Health Complex, Hathazari, Chittagong, Bangladesh.
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