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Effect of Population Selection on 99th Percentile Values for a High Sensitivity Cardiac Troponin I and T Assays.
MedLine Citation:
PMID:  23978509     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Using objective laboratory and clinical criteria to more accurately determine the 99th percentile values for cardiac troponin I and T.
DESIGN AND METHODS: We measured cardiac troponin T and cardiac troponin I with high-sensitiivty assays in a large cohort of apparently healthy community subjects and calculated 99th percentiles for different sexes and ages. Subjects with possible subclinical disease were eliminated based on objective laboratory criteria, eGFR and NT-proBNP, and clinical criteria, history and examination and echocardiogram.
RESULTS: For men and women of all ages, separately, more than 50% of subjects were excluded using these criteria, with a lesser proportion of younger subjects being excluded. In men aged <75 years, the 99th percentile for cTnI decreased by more than 50% from 22.9 ng/L to 10.3 ng/L. In other age groups and for cTnT the decrease was smaller (%) but still considerable.
CONCLUSIONS: For establishing cardiac troponin 99th percentiles, simply using self-reporting of health is insufficient. Objective laboratory measures and clinical and echocardiographic assessment is essential to define a healthy population, especially in older persons.
Authors:
Gus Koerbin; Walter P Abhayaratna; Julia M Potter; Fred S Apple; Allan S Jaffe; Tricia H Ravalico; Peter E Hickman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-23
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013. Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists. All rights reserved.
Affiliation:
ACT Pathology, Garran, ACT 2605, Australia; University of Canberra, ACT 2601, Australia.
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