| Effect of Polyphenols on Oxymyoglobin Oxidation: Prooxidant Activity of Polyphenols In Vitro and Inhibition by Amino Acids. | |
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MedLine Citation:
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PMID: 23311772 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Effects of various plant phenolics, including polyphenols, on the oxidation of oxymyoglobin were investigated. Most phenolics promoted the oxidation of oxymyoglobin at both pH 5.4 and 7.4. Potent oxidation-promoting activity was observed by several efficient antioxidant polyphenols with a catechol moiety. Therefore, effects of the catechol structure were investigated using dihydrocaffeic acid analogs. The results clarified that ortho- or para-substituted diphenol structures were important for promoting the oxidation of oxymyoglobin. Inhibition of such prooxidant activity for oxymyoglobin by dihydrocaffeic acid was also investigated. Although the required concentration was relatively higher than that of dihydrocaffeic acid, several amino acids inhibited oxidation. Among these, cysteine was the most potent. Although cysteine alone completely inhibited oxidation at a concentration above 1 mmol/L, 0.1 mmol/L of cysteine showed oxidation-promoting activity. In the presence of 0.1 mmol/L dihydrocaffeic acid, in the range of 0.01 mmol/L to 1 mmol/L of cysteine, 0.1 mmol/L of cysteine showed the most efficient inhibition. These results suggest one of the possibility of the formation of some equimolar complexes of dihydrocaffeic acid and cysteine such as 5'-cysteinyl dihydrocaffeic acid, which may be produced during the prooxidation of dihydrocaffeic acid, contributed to the inhibition of the oxidation of oxymyoglobin. |
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Authors:
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Toshiya Masuda; Miyuki Inai; Yukari Miura; Akiko Masuda; Satoshi Yamauchi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-13 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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