Document Detail


Effect of Pneumoperitoneum on Renal Tissue Oxygenation and Blood Flow in a Rat Model.
MedLine Citation:
PMID:  21507469     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To determine the correlation between the renal blood flow (RBF) and tissue oxygenation (PO(2)) at varying intra-abdominal pressures (IAPs) and to compare the effects on renal blood flow from carbon dioxide-induced pneumoperitoneum. METHODS: Carbon dioxide pneumoperitoneum was established in Sprague-Dawley rats (n = 6). Licox oxygen/temperature tissue probes were laparoscopically inserted into the renal parenchyma, with the renal PO(2) and RBF recorded every 30 seconds while the IAP was gradually increased. Microprobes measuring the RBF, mean arterial pressures and serum pH were placed into the parenchyma to compare the effects of carbon dioxide pneumoperitoneum (n = 7) with that of open surgery (n = 6) and medical air pneumoperitoneum (n = 6). RESULTS: Renal PO(2) was inversely related to the IAP (P < .001). Despite the reduction in IAP, the renal PO(2) in the recovery phase was lower than at baseline (P = .045). The renal PO(2) and RBF changed in a virtually identical pattern at varying levels of IAP (P > .05). The RBF significantly declined with a pneumoperitoneal pressure of 15 and 20 mm Hg (P = .022), regardless of the gas used to create the pneumoperitoneum. A partial reversal of the RBF occurred with a decrease of the IAP. The RBF in the open surgical arm remained unchanged. Although both the serum pH and the mean arterial pressure were inversely proportional to the IAP (P < .001), the mean arterial pressure was depressed to the greatest extent in the medical air group (P = .02). CONCLUSIONS: These results have demonstrated that elevated IAP secondary to pneumoperitoneum causes significant renal hypoxia and decreased RBF. Additionally, this experiment has demonstrated the use of the Licox probes in monitoring the renal PO(2) and established a novel method for evaluating the effects of IAP on the kidney.
Authors:
Joshua D Wiesenthal; Luke M Fazio; Alexandra E Perks; Brian D M Blew; David Mazer; Greg Hare; R John D'A Honey; Kenneth T Pace
Related Documents :
529319 - The relationship of diet to blood pressure control.
21300539 - Reduction of ammonia and volatile organic compounds from food waste-composting faciliti...
21456219 - Consolidation of binderless nanostructured tic by pulsed current activated sintering an...
21394089 - Ang ii upregulation of the t-lymphocyte renin-angiotensin system is amplified by low-gr...
19707489 - Automated pressure-controlled discography with constant injection speed and real-time p...
21127469 - The dominant role of the systolic component of nondipping status on target-organ damage...
2283189 - Oral metoprolol therapy in dilated cardiomyopathy: hemodynamic evidence for improved di...
10534699 - The intra-aortic cannula pump: a novel assist device for the acutely failing heart.
230169 - Modification of synaptic facilitation and bursting patterns in aplysia californica by h...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-18
Journal Detail:
Title:  Urology     Volume:  -     ISSN:  1527-9995     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Surgery, Division of Urology, Keenan Research Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Validation of Postoperative Nomograms in Prostate Cancer Patients with Long-term Follow-up.
Next Document:  Seminal Interleukin-6 and Serum Prostate-specific Antigen as Possible Predictive Biomarkers in Asymp...