| Effect of physical exertion on the biological monitoring of exposure to various solvents following exposure by inhalation in human volunteers: III. Styrene. | |
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MedLine Citation:
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PMID: 19412862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluated the impact of different work load intensities on biological indicators of styrene exposure. Four adult Caucasian men, aged 20 to 44 years, were recruited. Groups of 2-4 volunteers were exposed to 20 ppm of styrene in an exposure chamber according to scenarios involving either aerobic, muscular, or both types of physical exercise for 3 or 7 hr. The target intensities for each 30-min exercise period-interspaced with 15 min at rest-were the following: REST, 38 watts AERO (time-weighted average intensity), 34 watts AERO/MUSC, 49 watts AERO/MUSC, and 54 watts AERO for 7 hr and 22 watts MUSC for 3 hr. End-exhaled air samples were collected at 15 time points during and after 7-hr exposures for the determination of styrene concentrations. Urine samples were collected before the start of exposure, after the first 3 hr of exposure, and at the end of exposure for the determination of mandelic acid (MA) and phenylglyoxilic acid (PGA) concentrations. Compared with exposure at rest, styrene in alveolar air increased by a factor up to 1.7, while the sum of urinary MA and PGA increased by a factor ranging from 1.2 to 3.5, depending on the exposure scenario. Concentrations of biological indicators of styrene fluctuated with physical exertion and were correlated with the magnitude of the physical activity and pulmonary ventilation. Despite the physical exertion effect, urinary concentrations of styrene metabolites after a single-day exposure remain below the current biological exposure index value recommended by ACGIH; therefore, no additional health risk is expected. However, results shows that work load intensities must be considered in the interpretation of biological monitoring data and in the evaluation of the health risk associated with styrene exposure. |
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Authors:
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Ginette Truchon; Martin Brochu; Robert Tardif |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of occupational and environmental hygiene Volume: 6 ISSN: 1545-9632 ISO Abbreviation: J Occup Environ Hyg Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-05-04 Completed Date: 2009-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101189458 Medline TA: J Occup Environ Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 460-7 Citation Subset: IM |
Affiliation:
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Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST), Québec, Canada. truchon.ginette@irsst.qc.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Breath Tests Environmental Monitoring* Humans Inhalation Exposure / analysis* Male Physical Exertion* Pulmonary Ventilation Solvents / analysis* Styrene / analysis*, urine |
| Chemical | |
Reg. No./Substance:
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0/Solvents; 100-42-5/Styrene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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