Document Detail

Effect of Photodynamic Therapy, Diode Laser and Deep Scaling on Cytokine and Acute-Phase Protein Levels in Gingival Crevicular Fluid of Residual Periodontal Pockets.
MedLine Citation:
PMID:  22181685     Owner:  NLM     Status:  Publisher    
Background: There is an ongoing controversy on the benefits of treatment protocols including dental lasers and photodynamic therapy. The purpose of this study was to compare the local biological effects of photodynamic therapy (PDT), diode laser therapy (DSL) and conventional deep scaling and root planing (SRP) in residual pockets. Methods: 32 subjects were included based on a history of previous treatment for periodontitis and the persistence of sites with probing depths >4 mm and bleeding upon probing. Residual pockets were debrided with an ultrasonic device and then randomly assigned either to PDT, DSL or SRP. Gingival crevicular fluid was collected before treatment, after 14 days, 2 and 6 months. Levels of 13 cytokines and 9 acute-phase proteins were measured using a bead-based multiplexing analysis system. Results: Treatment with PDT, DSL or SRP led to significant changes in several cytokines and acute phase proteins: Compared to baseline, levels of IL-17, b-FGF, G-CSF, GM-CSF and MIP-1α were lower 14 days and 2 months after treatment. Except for G-CSF, these differences remained significant throughout the observation period. The levels of 5 acute-phase proteins (α2M, haptoglobulin, serum amyloid P, procalcitonin and tissue plasminogen activator) were significantly higher at 6 months than at baseline. No significant differences were observed between the 3 treatment modalities at any time point for any biochemical parameter. Conclusions: Levels of several cytokines and acute phase proteins significantly changed after treatment irrespectively of treatment modality. There was no evidence for a specific DSL- or PDT-enhanced expression of inflammatory mediators.
Catherine Giannopoulou; Isabelle Cappuyns; Jose Cancela; Norbert Cionca; Andrea Mombelli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-19
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Periodontology, University of Geneva, Switzerland.
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