Document Detail

Effect of Phenolic Compounds Against Aβ Aggregation and Aβ-Induced Toxicity in Transgenic C. elegans.
MedLine Citation:
PMID:  21858698     Owner:  NLM     Status:  Publisher    
Substantial evidence suggests that the aggregation of amyloid-β (Aβ) peptide into fibrillar structures that is rich in β-sheets is implicated as the cause of Alzheimer's disease. Therefore, an attractive therapeutic strategy is to prevent or alter Aβ aggregation. Phenolic compounds are natural substances that are composed of one or more aromatic phenolic rings and present in wine, tea, fruits, vegetables and a wide variety of plants. In this work, we investigated the effects of ferulic acid, morin, quercetin and gossypol against Aβ aggregation. From the ThT and turbidity assays, it is observed that in addition to the fibril aggregate, another type of aggregate is formed in the presence of morin, quercetin, and gossypol. On the other hand, ferulic acid did not prevent fibril formation, but it did appear to reduce the average length of fibrils compared to Aβ alone. To study the protective effects of phenolic compounds on Aβ-induced toxicity, we utilized the nematode Caenorhabditis elegans (C. elegans) as an in vivo model organism, human Aβ is expressed intracellularly in the body wall muscle. We found that exposure of Caenorhabditis elegans to ferulic acid give more protection against Aβ toxicity than morin, quercetin and gossypol.
Seema Jagota; Jayakumar Rajadas
Related Documents :
19527698 - First total synthesis and antiprotozoal activity of (z)-17-methyl-13-octadecenoic acid,...
16471868 - Synthesis of large-pore methylene-bridged periodic mesoporous organosilicas and its imp...
23995948 - Comparative study of pikeperch sander lucioperca (percidae; linnaeus, 1758) eggs and la...
16663528 - Rates and products of long-chain fatty acid synthesis from [1-c]acetate in chloroplasts...
3768958 - Mammalian multidrug resistance gene: complete cdna sequence indicates strong homology t...
12008968 - Occurrence, functions and biosynthesis of polyamides in microorganisms and biotechnolog...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-21
Journal Detail:
Title:  Neurochemical research     Volume:  -     ISSN:  1573-6903     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Bioorganic Laboratory, Central Leather Research Institute (CSIR), Adyar, Chennai, 600 020, India,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Davallialactone protects against adriamycin-induced cardiotoxicity in vitro and in vivo.
Next Document:  Hydrolysis of Substance P in the Presence of the Osteosarcoma Cell Line SaOS-2: Release of Free Amin...