Document Detail


Effect of Percutaneous Tracheostomy on Intracerebral Pressure and Perfusion Pressure in Patients with Acute Cerebral Dysfunction (TIP Trial): An Observational Study.
MedLine Citation:
PMID:  22539153     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Bedside percutaneous tracheostomy (PT) is very commonly used for patients who require prolonged mechanical ventilation. The effect of tracheostomy on intracranial pressure (ICP) is currently a subject of controversy. The aim of our study is to clarify the relation between PT and its effect on ICP and cerebral perfusion pressure. METHODS: 38 patients on our intensive care unit were included prospectively in an observational study. We examined mean values of HF, SpO(2), ICP, CPP, and MAP for changes over five different phases of the procedure using paired Mann-Whitney U tests. A p value of <0.05 was considered significant. p values were Bonferroni corrected for multiple testing. RESULTS: PT was performed on 38 patients (f = 19, m = 19; mean = 56 years). Median ICP before intervention was 9 mmHg. During positioning of the patient, ICP had risen to 14, during bronchoscopy to 16, and during tracheostomy to 18 mmHg, all being significantly higher than baseline level. Monitoring of MAP showed a significant increase to 101 mmHg only during tracheostomy. SpO(2) and HF did not show any significant changes. Mean duration of positioning, bronchoscopy and tracheostomy was 19, 10, and 17 min. 8 patients received osmotherapy due to a rise of ICP of more than 30 mmHg. CONCLUSION: PT only leads to a significant rise of ICP during the procedure. Nevertheless, therapy of ICP is necessary in some patients. From our point of view, therefore, tracheostomy should only be performed under continuous monitoring of ICP and CPP in patients with severe cerebral dysfunctions and critically elevated ICP.
Authors:
Jens Kleffmann; Roman Pahl; Wolfgang Deinsberger; Andreas Ferbert; Christian Roth
Related Documents :
18047913 - Beta-adrenergic receptor genes are associated with arterial stiffness in black and whit...
590023 - Prazosin combined with thiazide diuretic and beta-blocker in the treatment of hypertens...
20444953 - Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and d...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-27
Journal Detail:
Title:  Neurocritical care     Volume:  -     ISSN:  1556-0961     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neurosurgery, Klinikum Kassel, Mönchebergstraße 41-43, 34125, Kassel, Germany, jens.kleffmann@klinikum-kassel.de.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Solar energy harnessing in hexagonally arranged Si nanowire arrays and effects of array symmetry on ...
Next Document:  Critical appraisal of the 'wait and see' approach in rectal cancer for clinical complete responders ...