Document Detail

Effect of the PPAR-Alpha L162V polymorphism on the cardiovascular disease risk factor in response to n-3 polyunsaturated fatty acids.
MedLine Citation:
PMID:  19776627     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Dietary n-3 polyunsaturated fatty acids (PUFAs) decrease the risk of cardiovascular disease (CVD). Yet, genetic variations of the gene encoding the peroxisome proliferator-activated receptor-alpha (PPARalpha) can also modulate CVD risk factors. Since fatty acids, including n-3 PUFAs, are natural ligands of PPARalpha, a gene-diet interaction effect could be observed. AIMS: To examine whether n-3 PUFA- induced changes in CVD risk factors are influenced by the PPARalpha L162V polymorphism. METHODS: Fourteen men, carriers of the V162 allele and 14 L162 homozygotes, were matched according to age and body mass index. Subjects followed, for 8 weeks, a low-fat diet and then were supplemented daily with 5 g of fish oil for 6 weeks. RESULTS: Baseline characteristics were similar for both genotype groups. Independently of the genotype, the supplementation was associated with a significant decrease in plasma triacylglycerol and fasting glucose concentrations, diastolic blood pressure, and with an increase in total apolipoprotein B concentrations. The extent of the decrease in plasma triacylglycerol concentrations was comparable for both genotype groups (p < 0.03). A significant genotype-by-diet interaction effect was observed for plasma C-reactive protein concentrations (p = 0.01). CONCLUSIONS: The PPARalpha L162V polymorphism may contribute to the interindividual variability in the CVD risk factor response to n-3 PUFAs.
Dominique Caron-Dorval; Pascale Paquet; Ann-Marie Paradis; Iwona Rudkowska; Simone Lemieux; Patrick Couture; Marie-Claude Vohl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-06
Journal Detail:
Title:  Journal of nutrigenetics and nutrigenomics     Volume:  1     ISSN:  1661-6499     ISO Abbreviation:  J Nutrigenet Nutrigenomics     Publication Date:  2008  
Date Detail:
Created Date:  2009-09-24     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101299758     Medline TA:  J Nutrigenet Nutrigenomics     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Lipid Research Center, CHUQ-CHUL Pavilion, Québec, Canada.
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MeSH Terms
Amino Acid Substitution / genetics
Cardiovascular Diseases / etiology*,  genetics
Fatty Acids, Omega-3 / adverse effects*
Fatty Acids, Unsaturated / adverse effects
Gene Frequency
Genetic Predisposition to Disease
Leucine / genetics
Middle Aged
PPAR alpha / genetics*
Polymorphism, Single Nucleotide* / physiology
Risk Factors
Valine / genetics
Young Adult
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 0/PPAR alpha; 61-90-5/Leucine; 7004-03-7/Valine

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