Document Detail


Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD.
MedLine Citation:
PMID:  16446007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the effects of propionyl l-carnitine (PLC) on clinical and functional parameters, and markers of the overall oxidation state in patients with peripheral arterial disease (PAD) associated with non-insulin-dependent diabetes mellitus (NIDDM). DESIGN AND SETTING: Randomised, double-blind, clinical trial, conducted in the Unit of Medical Angiology of the University of Catania. PATIENTS AND INTERVENTIONS: Seventy-four patients with NIDDM-associated PAD were treated with PLC (2 g/day) or placebo for 12 months. MAIN OUTCOME MEASURES: Ankle/brachial index (ABI) and the distance of pain-free walking were evaluated at baseline, 6 and 12 months. Malondialdehyde, 4-hydroxynonenal, oxidation time of low-density lipoproteins, and nitrite/nitrate ratio were measured as indices of the overall oxidation profiles at baseline and 12 months. RESULTS: In the PLC group, ABI progressively increased (0.78, 0.83, and 0.88 at 0, 6 and 12 months, respectively). The distance of pain-free walking also improved (366.4, 441.9 and 519.8 m, respectively). In the placebo group, these parameters were relatively unchanged. Significant improvements in all parameters of the oxidative profile were seen in the PLC-treated group, with only minor variations observed in the placebo group. CONCLUSIONS: These results suggest that adjunct therapy with PLC may be warranted in type 2 diabetes-associated PAD.
Authors:
Signorelli Salvatore Santo; Neri Sergio; Di Pino Luigi; Marchese Giuseppe; Ferrante Margherita; Oliveri Conti Gea; Fallico Roberto; Celotta Gabriella; Pennisi Giuseppe; Anzaldi Massimiliano
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-01-30
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  72     ISSN:  0168-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-23     Completed Date:  2006-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  231-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Systemic Pathology, Medical Angiology Section, Italy. ssignore@unict.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Aldehydes / blood
Ankle / blood supply
Blood Glucose / analysis
Blood Pressure / drug effects
Brachial Artery / physiology
Carnitine / analogs & derivatives*,  pharmacology,  therapeutic use
Cholesterol, LDL / blood
Diabetes Mellitus, Type 2 / complications*
Diabetic Angiopathies / drug therapy*,  metabolism,  physiopathology
Double-Blind Method
Hemoglobin A, Glycosylated / analysis
Humans
Malondialdehyde / blood
Middle Aged
Oxidation-Reduction / drug effects
Pain Measurement / statistics & numerical data
Placebos / administration & dosage
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Blood Glucose; 0/Cholesterol, LDL; 0/Hemoglobin A, Glycosylated; 0/Placebos; 17298-37-2/propionylcarnitine; 29343-52-0/4-hydroxy-2-nonenal; 541-15-1/Carnitine; 542-78-9/Malondialdehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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