Document Detail

Effect of PGD on implantation and ongoing pregnancy rates in cases with predominantly macrocephalic spermatozoa.
MedLine Citation:
PMID:  15257825     Owner:  NLM     Status:  MEDLINE    
Although its occurrence is rare, the presence of large headed or macrocephalic spermatozoa and increased chromosomal abnormality has recently been reported by several groups. Moreover, when intracytoplasmic sperm injection (ICSI) was performed with samples containing macrocephalic spermatozoa, lower fertilization and implantation rates result in poor clinical outcome. In order to evaluate the impact of preimplantation genetic diagnosis (PGD) on implantation and ongoing pregnancy rates in these couples, the results of 23 PGD cycles were compared with non-PGD cycles (n = 60) as well as cycles with absolute teratozoospermia (having zero normal morphology) with (n = 14) or without PGD (n = 66). Out of 82 embryos biopsied in the macrocephalic sperm group, abnormalities were detected in 46.4% of the embryos analysed. Most of the abnormalities were trisomies (37.0%) and complex aneuploidies (51.9%). A 33.3% pregnancy rate was achieved by selectively transferring euploid embryos after PGD with the statistically higher implantation rate of 25.0% compared with non-PGD cycles (IR: 12.3%, P < 0.01). Moreover, only one missed abortion (14.3%) was observed in the PGD group, whereas seven of the 15 pregnancies resulted in abortion in the non-PGD group (46.7%). Preliminary results indicate that patients should be counselled for increased chromosomal abnormality and a possible beneficial effect of eliminating chromosomally abnormal embryos with PGD on a bortion rates.
S Kahraman; S Sertyel; N Findikli; Y Kumtepe; N Oncu; S Melil; S Unal; H Yelke; P Vanderzwalmen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  9     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-19     Completed Date:  2005-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  79-85     Citation Subset:  IM    
Istanbul Memorial Hospital ART and Genetics Centre, Piyale Pasa Bulvari, 80270, Okmeydani, Istanbul, Turkey.
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MeSH Terms
Abortion, Spontaneous
Case-Control Studies
Chromosome Aberrations*
Embryo Implantation*
Embryo, Mammalian / physiology
Pregnancy Outcome
Pregnancy Rate*
Preimplantation Diagnosis / methods*
Spermatozoa / pathology*,  physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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