Document Detail

Effect of PEEP on regional ventilation and perfusion in the mechanically ventilated preterm lamb.
MedLine Citation:
PMID:  2666596     Owner:  NLM     Status:  MEDLINE    
Improvement of gas exchange through closer matching of regional ventilation (V) and lung perfusion (Q) with the application of positive end-expiratory pressure (PEEP) was evaluated in vivo in six mechanically ventilated preterm lambs (107-126 days/145 days gestation). Changes in V and Q were determined from in vivo scintigraphic measurements in four lung regions with inhaled radioactive 81mKr, and infused 81mKr/dextrose and/or [99mTc]MAA as PEEP was applied at 2, 4, and 6 cm H2O in each animal. Dynamic compliance varied between 0.02 and 0.40 ml/cm H2O, which was consistent with surfactant deficiency. As PEEP was increased, the regional distribution of Q shifted from the rostral to the caudal lung regions (p less than 0.02 to less than 0.05), while that of V remained unchanged. Regional V/Q matching improved together with a trend towards improvement of arterial blood gases as PEEP was increased from 2 to 4 cm H2O. Pulmonary scintigraphy offers a noninvasive methodology for the quantitative assessment of regional V and Q matching in preterm lambs and may be clinically applicable to ventilated neonates.
J S Schlessel; H Susskind; D D Joel; A Bossuyt; W H Harrold; I Zanzi; A D Chanana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  30     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-08-29     Completed Date:  1989-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1342-50     Citation Subset:  IM    
Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030.
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MeSH Terms
Animals, Newborn / physiology*
Krypton Radioisotopes / diagnostic use
Lung / radionuclide imaging
Positive-Pressure Respiration*
Technetium Tc 99m Aggregated Albumin / diagnostic use
Ventilation-Perfusion Ratio*
Reg. No./Substance:
0/Krypton Radioisotopes; 0/Technetium Tc 99m Aggregated Albumin

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