| Effect of PEEP on regional ventilation and perfusion in the mechanically ventilated preterm lamb. | |
| | |
MedLine Citation:
|
PMID: 2666596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Improvement of gas exchange through closer matching of regional ventilation (V) and lung perfusion (Q) with the application of positive end-expiratory pressure (PEEP) was evaluated in vivo in six mechanically ventilated preterm lambs (107-126 days/145 days gestation). Changes in V and Q were determined from in vivo scintigraphic measurements in four lung regions with inhaled radioactive 81mKr, and infused 81mKr/dextrose and/or [99mTc]MAA as PEEP was applied at 2, 4, and 6 cm H2O in each animal. Dynamic compliance varied between 0.02 and 0.40 ml/cm H2O, which was consistent with surfactant deficiency. As PEEP was increased, the regional distribution of Q shifted from the rostral to the caudal lung regions (p less than 0.02 to less than 0.05), while that of V remained unchanged. Regional V/Q matching improved together with a trend towards improvement of arterial blood gases as PEEP was increased from 2 to 4 cm H2O. Pulmonary scintigraphy offers a noninvasive methodology for the quantitative assessment of regional V and Q matching in preterm lambs and may be clinically applicable to ventilated neonates. |
| | |
Authors:
|
J S Schlessel; H Susskind; D D Joel; A Bossuyt; W H Harrold; I Zanzi; A D Chanana |
Related Documents
:
|
18825366 - Interactions between respiration and systemic hemodynamics. part ii: practical implicat... 17467866 - Successful conservative management with positive end-expiratory pressure for massive ha... 16356246 - Clinical review: positive end-expiratory pressure and cardiac output. 3893886 - Left ventricular geometry during positive end-expiratory pressure in dogs. 4703096 - Value of cuff occlusion pressures in assessment of peripheral vascular disease. 1707326 - Chronic nerve growth factor treatment of normotensive rats. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 30 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1989 Aug |
Date Detail:
|
Created Date: 1989-08-29 Completed Date: 1989-08-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1342-50 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn / physiology* Krypton Radioisotopes / diagnostic use Lung / radionuclide imaging Positive-Pressure Respiration* Sheep Technetium Tc 99m Aggregated Albumin / diagnostic use Ventilation-Perfusion Ratio* |
| Chemical | |
Reg. No./Substance:
|
0/Krypton Radioisotopes; 0/Technetium Tc 99m Aggregated Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of the skin in nosocomial infection: a review.
Next Document: Klebsiella pneumoniae osteomyelitis: demonstration by three-phase radionuclide bone imaging.