Document Detail

Effect of PEEP on lung water content in experimental noncardiogenic pulmonary edema.
MedLine Citation:
PMID:  6780267     Owner:  NLM     Status:  MEDLINE    
After administration of monocrotaline to dogs to produce noncardiogenic pulmonary edema, one-half of the animals (controls) were treated with intermittent positive pressure breathing (IPPV), and one-half with that ventilation plus the addition of 10 cm H2O of positive end-expiratory pressure (PEEP). After 6 h, the animals treated with PEEP demonstrated significantly better arterial oxygenation and reduced AaDO2, but lung water, quantitated either postmortem or in vivo by indicator-dilution techniques, was no less than controls. Although PEEP improves gas exchange, it fails to modify the degree of pulmonary edema represent.
W C Miller; D L Rice; K M Unger; B L Bradley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  9     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-9     Citation Subset:  AIM; IM    
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MeSH Terms
Body Water / analysis*
Intermittent Positive-Pressure Breathing
Lung / physiopathology*
Oxygen / blood,  physiology
Positive-Pressure Respiration*
Pulmonary Edema / chemically induced,  physiopathology*,  therapy
Pyrrolizidine Alkaloids
Reg. No./Substance:
0/Pyrrolizidine Alkaloids; 315-22-0/Monocrotaline; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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