Document Detail


Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis.
MedLine Citation:
PMID:  22567272     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology.
Authors:
Eduard Baquero; Wiston Quiñones; Wellman Ribon; Maria Leonor Caldas; Ladys Sarmiento; Fernando Echeverri
Publication Detail:
Type:  Journal Article     Date:  2011-04-11
Journal Detail:
Title:  Tuberculosis research and treatment     Volume:  2011     ISSN:  2090-1518     ISO Abbreviation:  Tuberc Res Treat     Publication Date:  2011  
Date Detail:
Created Date:  2012-05-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576351     Medline TA:  Tuberc Res Treat     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  986409     Citation Subset:  -    
Affiliation:
Grupo de Química Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Carrera 53 No. 61-30, Laboratorio 234, Medellín 50010, Colombia.
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