| Effect of oral zinc supplementation on the growth of preterm infants. | |
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MedLine Citation:
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PMID: 20308765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effect of oral zinc supplementation on growth of preterm infants. DESIGN: Randomized controlled trial. SETTING: Dhaka Shisu Hospital (Tertiary care hospital). SUBJECTS: 100 appropriate for date preterm infants weighing between 1000 to 2500 g were randomized to receive zinc and multivitamin supplement (Group I; n=50) or only multivitamin supplement (Group II). Intervention: Zinc supplementation was given 2mg/kg/day for 6 weeks along with multivitamin in Group I and only multivitamin to Group II. PRIMARY OUTCOME VARIABLE: Increment of weight and length. RESULTS: At enrollment, serum zinc (62.1 ± 12.4 ug/dL in Group I and 63.1 ± 14.6 ug/dL in Group II) and hemoglobin levels (14.9 ± 2.4 g/dL in Group I and 14.4 ± 1.7 g/dL in Group II) were almost similar in both groups. Serum zinc levels were in lower limit of normal range. After supplementation, serum zinc and hemoglobin levels were significantly higher in Group I (105 ± 16.5 ug/dL) than Group II (82.2 ± 17.4 ug/dL) (P<0.05). Weight, length and head circumference were comparable in both groups at enrollment. Significant differences in weight gain and increment in length were found in first and second follow up between two groups but OFC increments were not significant (P>0.05). Reduction of morbidity was apparent in zinc supplemented group. No serious adverse effect was noted related to supplementation therapy. CONCLUSION: Zinc supplementation for preterm low birth weight babies is found effective to enhance the growth in early months of life. |
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Authors:
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M N Islam; M A K A Chowdhury; M Siddika; S B Qurishi; M K J Bhuiyan; M M Hoque; S Akhter |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-01-15 |
Journal Detail:
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Title: Indian pediatrics Volume: 47 ISSN: 0974-7559 ISO Abbreviation: Indian Pediatr Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-04 Completed Date: 2011-02-23 Revised Date: 2011-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985062R Medline TA: Indian Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 845-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Mymensingh Medical College Hospital, Mymensingh, Bangladesh. mnislamdr1@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Cephalometry Dietary Supplements* Double-Blind Method Hemoglobins / analysis Humans Infant, Newborn Infant, Premature / blood, growth & development* Vitamins / administration & dosage Weight Gain Zinc / administration & dosage*, blood |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Vitamins; 7440-66-6/Zinc |
| Comments/Corrections | |
Comment In:
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Indian Pediatr. 2011 Sep;48(9):740
[PMID:
21992914
]
Indian Pediatr. 2010 Oct;47(10):841-2 [PMID: 21048236 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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