| Effect of ONO-3144, a free radical scavenger, on reoxygenation injury in anoxic myocardium. | |
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MedLine Citation:
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PMID: 2959083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thus, ONO-3144 treatment affords great protection against reoxygenation injury in the anoxic myocardium through the scavenging mechanism that includes .OH or closely related species of free radicals and also may inhibit thromboxane synthetase in the anoxic myocardium. We would hypothesize that free radical formation generated through the conversion of PGG2 to PGH2 should play an important role in the reoxygenation injury of the anoxic myocardium. |
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Authors:
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H Kobayashi; K Kobayashi; Y Hirohata; K Aihara; T Ohtsuka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in prostaglandin, thromboxane, and leukotriene research Volume: 17A ISSN: 0732-8141 ISO Abbreviation: Adv. Prostaglandin Thromboxane Leukot. Res. Publication Date: 1987 |
Date Detail:
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Created Date: 1987-11-19 Completed Date: 1987-11-19 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8211444 Medline TA: Adv Prostaglandin Thromboxane Leukot Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 388-91 Citation Subset: IM |
Affiliation:
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Central Institute for Electron Microscopic Researches, Nippon Medical School, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Anoxia / drug therapy*, pathology, physiopathology Calcium / metabolism Creatine Kinase / secretion Free Radicals Heart Diseases / drug therapy*, pathology, physiopathology Propiophenones / pharmacology* Rats |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 0/Propiophenones; 56-65-5/Adenosine Triphosphate; 7440-70-2/Calcium; 75060-92-3/2-aminomethyl-4-tert-butyl-6-propionylphenol; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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