Document Detail

Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases.
MedLine Citation:
PMID:  14669258     Owner:  NLM     Status:  MEDLINE    
Nigella sativa (black seed) is an important medicinal herb. In many Arabian, Asian and African countries, black seed oil is used as a natural remedy for a wide range of diseases, including various allergies. The plant's mechanism of action is still largely unknown. Due to the lack of study data on its efficacy in allergies, four studies on the clinical efficacy of Nigella sativa in allergic diseases are presented. In these studies, a total of 152 patients with allergic diseases (allergic rhinitis, bronchial asthma, atopic eczema) were treated with Nigella sativa oil, given in capsules at a dose of 40 to 80 mg/kg/day. The patients scored the subjective severity of target symptoms using a predefined scale. The following laboratory parameters were investigated: IgE, eosinophil count, endogenous cortisol in plasma and urine, ACTH, triglycerides, total cholesterol, LDL and HDL cholesterol and lymphocyte subpopulations. The score of subjective feeling decreased over the course of treatment with black seed oil in all four studies. A slight decrease in plasma triglycerides and a discrete increase in HDL cholesterol occurred while the lymphocyte subpopulations, endogenous cortisol levels and ACTH release remained unchanged. Black seed oil therefore proved to be an effective adjuvant for the treatment of allergic diseases.
Ulrich Kalus; Axel Pruss; Jaromir Bystron; Moric Jurecka; Alice Smekalova; Johannes Josef Lichius; Holger Kiesewetter
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  17     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-11     Completed Date:  2004-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1209-14     Citation Subset:  IM    
Copyright Information:
Copyright 2003 John Wiley & Sons, Ltd.
Humboldt University, Berlin, School of Medicine, Institute for Transfusion Medicine, Charité University Hospital, Berlin, Germany.
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MeSH Terms
Administration, Oral
Adrenocorticotropic Hormone / blood,  drug effects
Anti-Allergic Agents / administration & dosage,  pharmacology*,  therapeutic use
Child, Preschool
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Cross-Over Studies
Double-Blind Method
Eosinophils / drug effects
Hydrocortisone / blood,  urine
Immunoglobulin E / drug effects
Lymphocyte Subsets / drug effects
Middle Aged
Nigella sativa*
Plant Oils / administration & dosage,  pharmacology*,  therapeutic use
Respiratory Hypersensitivity / blood,  drug therapy*,  psychology
Triglycerides / blood
Reg. No./Substance:
0/Anti-Allergic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Plant Oils; 0/Triglycerides; 37341-29-0/Immunoglobulin E; 50-23-7/Hydrocortisone; 57-88-5/Cholesterol; 9002-60-2/Adrenocorticotropic Hormone

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