| Effect of N-dicyclopropylmethyl-amino-2-oxazoline (S-3341) on antioxidant status and nitric oxide in hypertensive patients. | |
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MedLine Citation:
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PMID: 9704198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Defective endothelium-dependent vascular relaxation has been found in animal models of hypertension and in hypertensive patients. An imbalance due to reduced production of nitric oxide (NO) or increased production of free radicals, mainly the superoxide anion, may facilitate the development of an arterial functional spasm. Although it has been shown that many antihypertensive drugs can normalise both the antioxidant activity and NO, the antioxidant effect of N-dicyclopropylmethyl-amino-2-oxazoline (S-3341), an alpha-adrenoreceptor agonist, has not been investigated. In this study we investigated the antioxidant and NO status in hypertensive patients and whether there was any effect of S-3341 on these parameters. Eleven patients with mild hypertension (mean systolic blood pressure 159.5 +/- 2.5 mmHg) were administered S-3341 (1 mg/day) for 4 weeks. Plasma vitamin E, nitrite-nitrate and MDA levels, and catalase activity, were measured both before and after treatment with S-3341. There was significant reduction in both mean systolic and diastolic blood pressure during the treatment. We found an increase in catalase activity (p < 0.05), a decrease in malondialdehyde (MDA) levels (p < 0.01) and an insignificant increase in vitamin E levels in hypertensive patients following the S-3341 treatment. We propose that S-3341 may prevent oxidant stress in hypertensive patients by inhibiting free-radical formation. |
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Authors:
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B Sözmen; C Kazaz; D Taşkiran; S Tüzün; E Y Sözmen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current medical research and opinion Volume: 14 ISSN: 0300-7995 ISO Abbreviation: Curr Med Res Opin Publication Date: 1998 |
Date Detail:
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Created Date: 1998-10-19 Completed Date: 1998-10-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0351014 Medline TA: Curr Med Res Opin Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 89-96 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Atatürk State Hospital, Izmir, Turkey. sozmen@bornova.ege.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antihypertensive Agents / therapeutic use* Antioxidants / therapeutic use* Blood Pressure / drug effects Catalase / blood Humans Hypertension / drug therapy*, physiopathology Male Malondialdehyde / blood Middle Aged Nitrates / blood Nitric Oxide / blood* Nitrites / blood Oxazoles / therapeutic use* Vitamin E / blood |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Antioxidants; 0/Nitrates; 0/Nitrites; 0/Oxazoles; 10102-43-9/Nitric Oxide; 1406-18-4/Vitamin E; 54187-04-1/rilmenidine; 542-78-9/Malondialdehyde; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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