Document Detail

Effect of N-butylscopolamine on sphincter of Oddi motility in patients during routine ERCP--a manometric study.
MedLine Citation:
PMID:  2209497     Owner:  NLM     Status:  MEDLINE    
N-butylscopolamine is a generally accepted drug for the suppression of gut motility. Although it is used during routine ERCP, only few systematic studies have been carried out in patients to investigate its action on sphincter of Oddi motility. In the present study the effect of N-butylscopolamine on the motility of the sphincter of Oddi region has been evaluated in 17 patients undergoing routine diagnostic ERCP. The pressure parameters of these patients were compared with "normal values" obtained in 23 volunteers. A dose of 40 mg of N-butylscopolamine bromide (Buscopan) i.v. significantly reduced the contraction frequency of the sphincter of Oddi from 5.4 +/- 1.2/min to 1.0 +/- 1.4/min (p less than 0.001), the contraction amplitude from 106.3 +/- 27.8 mmHg to 55.2 +/- 23.5 (p less than 0.01) mmHg, and the basal sphincter of Oddi pressure from 13.9 +/- 3.0 mmHg to 11.0 +/- 3.5 mmHg (p less than 0.05), but had no effect on the pressure gradient between the common bile duct and the duodenum. These results clearly demonstrate that N-butylscopolamine inhibits contractions of the sphincter of Oddi, and may thus facilitate the intubation of the papilla.
H D Allescher; H Neuhaus; F Hagenmüller; M Classen
Related Documents :
16455787 - Comparison of rectoanal axial forces in health and functional defecatory disorders.
24724487 - Association between decreased blood pressure and azotaemia in canine babesiosis.
21274107 - The physician's approach to hypertension in the office.
15259487 - Evaluation of the upper esophageal sphincter (ues) using simultaneous high-resolution e...
1090987 - Respiratory and cough mechanics in antitussive trials. responsivity of objective indice...
17420337 - Adiponectin level and left ventricular hypertrophy in japanese men.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Endoscopy     Volume:  22     ISSN:  0013-726X     ISO Abbreviation:  Endoscopy     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-11-09     Completed Date:  1990-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  160-3     Citation Subset:  IM    
II. Medizinische Klinik und Poliklinik der Technischen Universität München, BRD.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Butylscopolammonium Bromide / pharmacology*
Cholangiopancreatography, Endoscopic Retrograde*
Depression, Chemical
Middle Aged
Peristalsis / drug effects
Reference Values
Sphincter of Oddi / drug effects*,  physiology
Reg. No./Substance:
149-64-4/Butylscopolammonium Bromide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Injection therapy of bleeding peptic ulcer. A prospective, randomized trial using epinephrine and th...
Next Document:  Antibiotic prophylaxis of infectious complications with endoscopic retrograde cholangiopancreatograp...