Document Detail


Effect of N-butylscopolamine on sphincter of Oddi motility in patients during routine ERCP--a manometric study.
MedLine Citation:
PMID:  2209497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-butylscopolamine is a generally accepted drug for the suppression of gut motility. Although it is used during routine ERCP, only few systematic studies have been carried out in patients to investigate its action on sphincter of Oddi motility. In the present study the effect of N-butylscopolamine on the motility of the sphincter of Oddi region has been evaluated in 17 patients undergoing routine diagnostic ERCP. The pressure parameters of these patients were compared with "normal values" obtained in 23 volunteers. A dose of 40 mg of N-butylscopolamine bromide (Buscopan) i.v. significantly reduced the contraction frequency of the sphincter of Oddi from 5.4 +/- 1.2/min to 1.0 +/- 1.4/min (p less than 0.001), the contraction amplitude from 106.3 +/- 27.8 mmHg to 55.2 +/- 23.5 (p less than 0.01) mmHg, and the basal sphincter of Oddi pressure from 13.9 +/- 3.0 mmHg to 11.0 +/- 3.5 mmHg (p less than 0.05), but had no effect on the pressure gradient between the common bile duct and the duodenum. These results clearly demonstrate that N-butylscopolamine inhibits contractions of the sphincter of Oddi, and may thus facilitate the intubation of the papilla.
Authors:
H D Allescher; H Neuhaus; F Hagenmüller; M Classen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Endoscopy     Volume:  22     ISSN:  0013-726X     ISO Abbreviation:  Endoscopy     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-11-09     Completed Date:  1990-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  160-3     Citation Subset:  IM    
Affiliation:
II. Medizinische Klinik und Poliklinik der Technischen Universität München, BRD.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Butylscopolammonium Bromide / pharmacology*
Cholangiopancreatography, Endoscopic Retrograde*
Depression, Chemical
Female
Humans
Male
Manometry
Middle Aged
Peristalsis / drug effects
Reference Values
Sphincter of Oddi / drug effects*,  physiology
Chemical
Reg. No./Substance:
149-64-4/Butylscopolammonium Bromide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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