Document Detail

Effect of N-acetylcysteine on endothelial dysfunction in dialysis patients.
MedLine Citation:
PMID:  17643057     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Patients with K/DOQI stage 5 chronic kidney disease (CKD) have higher incidence of cardiovascular events due to the oxidative stress and endothelial dysfunction (ED). The aim of this study is to evaluate the effects of N-acetylcysteine (NAC), which might prevent cardiovascular events by improving oxidative stress on endothelial cells in patients with CKD. METHODS: Thirty uremic patients (age 40 +/- 12 years, 6 males) on hemodialysis (HD) were evaluated for ED by using high-resolution Doppler ultrasound of brachial artery before and after 6 weeks of oral NAC (2 x 600 mg) medication. Also, 13 healthy controls (35 +/- 9 years, 5 males) were included in the study. Reactive hyperemia following 5 min forearm ischemia was accepted as endothelium-dependent vasodilatation (flow-mediated dilatation; FMD) and compared to endothelium-independent vasodilatation in response to sublingual glyceril trinitrate (GTN). RESULTS: Patients on HD had lower DeltaFMD (0.28 +/- 0.17 vs. 0.41 +/- 0.11, p < 0.05) and FMD% (7.5 +/- 5.05 vs. 11.33 +/- 2.95, p < 0.05) than the controls. Baseline DeltaGTN and GTN% were similar in two groups. NAC treatment significantly increased the DeltaFMD (0.41 +/- 0.11, p < 0.001 vs. baseline) and FMD% (10.59 +/- 3.22, p < 0.01 vs. baseline) of patients on HD, while it had no effect on DeltaGTN and GTN%. CONCLUSION: These results suggest that NAC treatment could improve the ED by preventing the reduction of FMD in patients on HD.
Garip Sahin; Ahmet Ugur Yalcin; Nevbahar Akcar
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2007-07-20
Journal Detail:
Title:  Blood purification     Volume:  25     ISSN:  1421-9735     ISO Abbreviation:  Blood Purif.     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-24     Completed Date:  2007-10-15     Revised Date:  2008-11-18    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  309-15     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Department of Nephrology, Osmangazi University Medical School, Eskisehir, Turkey.
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MeSH Terms
Acetylcysteine / pharmacology,  therapeutic use*
Antioxidants / pharmacology,  therapeutic use*
Brachial Artery / drug effects,  physiopathology,  ultrasonography
Cardiovascular Diseases / etiology,  prevention & control*
Endothelium, Vascular / drug effects*,  physiopathology
Middle Aged
Nitric Oxide / physiology
Nitroglycerin / diagnostic use
Oxidative Stress / drug effects
Renal Dialysis*
Uremia / blood,  therapy*
Vasodilation / drug effects
Reg. No./Substance:
0/Antioxidants; 10102-43-9/Nitric Oxide; 55-63-0/Nitroglycerin; 616-91-1/Acetylcysteine
Comment In:
Blood Purif. 2008;26(4):354   [PMID:  18487879 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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