Document Detail

Effect of modest salt reduction on skin capillary rarefaction in white, black, and Asian individuals with mild hypertension.
MedLine Citation:
PMID:  20585106     Owner:  NLM     Status:  MEDLINE    
Microvascular rarefaction occurs in hypertension. We carried out a 12-week randomized double-blind crossover trial to determine the effect of a modest reduction in salt intake on capillary rarefaction in 71 whites, 69 blacks, and 29 Asians with untreated mildly raised blood pressure. Both basal and maximal (during venous congestion) skin capillary density were measured by capillaroscopy at the dorsum and the side of the fingers. In addition, we used orthogonal polarization spectral imaging to measure skin capillary density at the dorsum of the fingers and the hand web. With a reduction in salt intake from 9.7 to 6.5 g/day, there was an increase in capillary density (capillaries per millimeter squared) from 101+/-21 to 106+/-23 (basal) and 108+/-22 to 115+/-22 (maximal) at the dorsum, and 101+/-25 to 107+/-26 (basal) and 110+/-26 to 116+/-26 (maximal) at the side of the fingers (P<0.001 for all). Orthogonal polarization spectral imaging also showed a significant increase in capillary density both at the dorsum of the fingers and the web. Subgroup analysis showed that most of the changes were significant in all of the ethnic groups. Furthermore, there was a significant relationship between the change in 24-hour urinary sodium and the change in capillary density at the side of the fingers. These results demonstrate that a modest reduction in salt intake, as currently recommended, improves both functional and structural capillary rarefactions that occur in hypertension, and a larger reduction in salt intake would have a greater effect. The increase in capillary density may possibly carry additional beneficial effects on target organs.
Feng J He; Maciej Marciniak; Nirmala D Markandu; Tarek F Antonios; Graham A MacGregor
Related Documents :
1760376 - Chronic effects of high salt intake and conflict stress on blood pressure in primates. ...
23233496 - Comparison of 2 correction methods for absolute values of esophageal pressure in subjec...
7298136 - Effect of salt loading on the cardiovascular response to stress in adolescents.
12969876 - Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal respon...
1247146 - Peripheral vasopressin for safe and adequate control of portal hypertension during shun...
17970236 - The use of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-06-28
Journal Detail:
Title:  Hypertension     Volume:  56     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  253-9     Citation Subset:  IM    
Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
African Continental Ancestry Group
Aldosterone / blood
Asian Continental Ancestry Group
Capillaries / anatomy & histology,  physiopathology*
Diet, Sodium-Restricted*
Double-Blind Method
European Continental Ancestry Group
Fingers / blood supply
Hemoglobins / metabolism
Hypertension / blood,  physiopathology*,  prevention & control*
Microscopy, Video / methods
Middle Aged
Polarography / methods
Renin / blood
Skin / blood supply*
Systole / physiology
Reg. No./Substance:
0/Hemoglobins; 0/Placebos; 52-39-1/Aldosterone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Testicular cancer survivorship: research strategies and recommendations.
Next Document:  Meta-analysis of genome-wide gene expression differences in onset and maintenance phases of genetic ...