Document Detail


Effect of Minimized Perfusion Circuit on Brain Injury Markers Carnosinase and Brain-Type Fatty Binding Protein in Coronary Artery Bypass Grafting Patients.
MedLine Citation:
PMID:  23020859     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A minimized perfusion circuit (MPC) has proven to be superior to the conventional circulatory perfusion bypass (CCPB) as it reduces the blood-material interaction and hemodilution. Until now not much is known about impact these different perfusion systems have on the brain. The objective of this study is to determine carnosinase and brain-type fatty binding protein (BFABP) activity as novel specific biomarkers for ischemic brain tissue damage and how their activity differs during and after MPC and CCPB as well as to compare the inflammatory response of both perfusion systems. In a prospective pilot study, 28 patients undergoing coronary artery bypass grafting were randomly divided into an MPC group (n = 14) and a CCPB group (n = 14). Blood samples were taken before, during, and after operation until the fifth postoperative day. The brain biomarker carnosinase was determined by measuring the rate of histidine production from the substrate homocarnosine, whereas BFABP and interleukin-6 were determined by enzyme-linked immunosorbent assay (ELISA). C-reactive protein (CRP) and endothelin-1 were determined by enzyme immunoassay. The mean serum carnosinase activity was significantly higher in MPC (0.57 ± 0.34 nM histidine/mL/min) as compared with the CCPB group (0.36 ± 0.13 nM histidine/mL/min) at the end of operation (P = 0.02). The BFABP did not show any difference between the two groups in the immediate postoperative period until the second postoperative day. From that time point onward, it showed a steep increase in the CCPB group (581.3 ± 157.11 pg/mL) as compared with the concentrations in the MPC group (384.6 ± 39 pg/mL) (P = 0.04). The inflammation markers interleukin-6 and CRP showed a similar pattern in both groups without significant difference. In contrast, the leukocyte count on operation day and endothelin-1 on the first postoperative day were significantly higher in the CCPB group (P = 0.01, P = 0.03, respectively). MPC showed a significant higher and stable serum carnosinase activity during extracorporeal circulation as compared with the CCPB due to less hemodilution and a better preserved oxygen capacity. As a consequence, the antioxidant stress during MPC is limited as compared with CCPB, which means less brain tissue damage reflected by a lower BFABP release. Except endothelin-1 and leukocyte count, the inflammatory response of the MPC and CCPB was equal.
Authors:
Dipak R Pahari; Y John Gu; Willem van Oeveren; Aschraf El-Essawi; Wolfgang Harringer; René M H Brouwer
Related Documents :
19603139 - Chronic pelvic abscedation after completion proctectomy in an irradiated pelvis: anothe...
24165669 - A prospective clinical study of flow-mediated dilatation in burn injury.
6751459 - The lateral paramedian incision--experience with 850 cases.
24680309 - Outcomes after repair of chronic bucket-handle tears of medial meniscus.
2394619 - Preliminary results of a pilot study of pentoxifylline in the treatment of late radiati...
23601259 - Reinsertion of the stylet does not affect incidence of post dural puncture headaches (p...
11416509 - Early and intermediate outcomes after rotational atherectomy in octogenarian patients.
24618389 - Aortic valve repair with patch in non-rheumatic disease: indication, techniques and dur...
10614889 - Total knee arthroplasty for post-traumatic arthrosis.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-30
Journal Detail:
Title:  Artificial organs     Volume:  -     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012, Copyright the Authors. Artificial Organs © 2012, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
Affiliation:
Department of Cardiothoracic and Vascular Surgery, Städtisches Klinikum Braunschweig, Braunschweig, Germany Department of Biomedical Engineering, University Medical Center Groningen Focus Group for Research and Development, Haemoscan B.V., Groningen, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a huma...
Next Document:  Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of th...