Document Detail


The effect of microgravity on ocular structures and visual function: a review.
MedLine Citation:
PMID:  23369516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ocular structural and functional changes, including optic disk edema and reduction of near visual acuity, have been recently described in some astronauts returning from long-duration space travels. It is hypothesized that ocular changes related to spaceflight may occur, in predisposed individuals, as a result of cephalad shift of body fluids, possibly leading to elevated intracranial pressure (ICP). Results from head-down bed-rest studies (used to simulate the effects of microgravity) and from parabolic flight experiments (used to produce transient periods of microgravity) indicate that ocular blood flow and intraocular pressure (IOP) may undergo changes in a low-gravity environment. Recent studies suggest that changes in translaminar pressure (i.e., IOP minus ICP) may be implicated in the pathophysiology of optic disk neuropathies. Because postural changes exert an effect on both IOP and ICP, the head-down bed-rest analog may also be used as a platform to characterize the relationship between IOP and ICP, and their reciprocal influence in the pathophysiology of conditions such as optic disk edema or glaucoma.
Authors:
Giovanni Taibbi; Ronita L Cromwell; Kapil G Kapoor; Bernard F Godley; Gianmarco Vizzeri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-29
Journal Detail:
Title:  Survey of ophthalmology     Volume:  58     ISSN:  1879-3304     ISO Abbreviation:  Surv Ophthalmol     Publication Date:    2013 Mar-Apr
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-06-07     Revised Date:  2013-07-09    
Medline Journal Info:
Nlm Unique ID:  0404551     Medline TA:  Surv Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, Galveston, TX 77555-1106, USA.
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MeSH Terms
Descriptor/Qualifier:
Astronauts
Eye / blood supply*
Head-Down Tilt
Humans
Intracranial Pressure*
Intraocular Pressure*
Papilledema / etiology
Space Flight
Weightlessness / adverse effects*
Grant Support
ID/Acronym/Agency:
UL1 RR029876/RR/NCRR NIH HHS; UL1 TR000071/TR/NCATS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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