| The effect of metal imbalances on scrapie neurodegeneration. | |
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MedLine Citation:
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PMID: 19486493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Environmental exposure to metal appears to enhance susceptibility to Transmissible Spongiform Encephalopathies (TSEs); however, published data are not conclusive. The current study focuses on assessing the effects of copper depletion and/or manganese enhancement in the diet on susceptibility to Scrapie and this disease progression. The degree of spongiosis was the highest in the animals that received a copper- depleted diet. These observations suggest that this diet contributes to the Scrapie lesions and to the worsening of the condition in animals that have been inoculated with Scrapie. The highest intensities of GFAP immunostaining were also associated with the copper- depleted diet. Dietary supplementation with manganese had a negative effect on neuronal counts. In conclusion, this study demonstrates that certain environmental factors may aggravate neuropathological Scrapie lesions. This is consistent with reports from other neurodegenerative diseases where some metalloenzymes play a pivotal protector role against the oxidative stress associated with pathogenesis. |
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Authors:
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P Hortells; E Monleón; C Acín; A Vargas; V Vasseur; A Salomon; B Ryffel; J Y Cesbron; J J Badiola; M Monzón |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-08 |
Journal Detail:
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Title: Zoonoses and public health Volume: 57 ISSN: 1863-2378 ISO Abbreviation: Zoonoses Public Health Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-14 Completed Date: 2010-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101300786 Medline TA: Zoonoses Public Health Country: Germany |
Other Details:
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Languages: eng Pagination: 358-66 Citation Subset: IM |
Affiliation:
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Research Centre for Prion Diseases, University of Zaragoza, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animal Nutritional Physiological Phenomena Animals Brain / pathology Copper / deficiency*, metabolism Diet Dietary Supplements Manganese / pharmacology* Metals / metabolism*, pharmacology Mice Prions / genetics, metabolism Scrapie / metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Metals; 0/Prions; 0/Prnp protein, mouse; 7439-96-5/Manganese; 7440-50-8/Copper |
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