Document Detail

Effect of Melothria maderaspatana leaf-tea consumption on blood pressure, lipid profile, anthropometry, fibrinogen, bilirubin, and albumin levels in patients with hypertension.
MedLine Citation:
PMID:  17480136     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effect of Melothria maderaspatana (Linn.) leaf-tea on blood pressure, plasma lipid profile, fibrinogen, albumin together with serum bilirubin and anthropometric measurements in volunteer participants with hypertension, because all these variables have been shown to influence vascular events. SUBJECTS AND DESIGN: A total of 50 subjects-25 (mean age of 58 +/- 9.0 years; 12 were women) with mild-to-moderate hypertension (systolic blood pressure [SBP] >or= 140 mm Hg; diastolic blood pressure [DBP] >or= 90 mm Hg) and 25 normotensives (mean age of 48 +/- 8.0 years; 11 women)-were selected for this study. Plasma lipid profile, fibrinogen, albumin, serum bilirubin, and anthropometric measurements were measured at baseline and after leaf-tea consumption by the patient with hypertension for 45 days. RESULTS: SBP and DBP gradually decreased and pulse rate decreased. The total cholesterol, low-density lipoprotein cholesterol and triglycerides, and phospholipids levels decreased significantly and high-density lipoprotein cholesterol and serum bilirubin levels increased after tea consumption in patients with hypertension. We also observed significant body weight loss and reduction in fibrinogen levels. There was no significant difference in plasma level of albumin. CONCLUSIONS: Thus, M. maderaspatana leaf-tea consumption gradually decreased BP and showed beneficial effects on blood lipid profile, fibrinogen, bilirubin, and body mass index in patients with hypertension.
Boobalan Raja; Kuppusamy Kaviarasan; Mangalam Muthu Arjunan; Kodukkur Viswanathan Pugalendi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of alternative and complementary medicine (New York, N.Y.)     Volume:  13     ISSN:  1075-5535     ISO Abbreviation:  J Altern Complement Med     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-07     Completed Date:  2007-06-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9508124     Medline TA:  J Altern Complement Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  349-54     Citation Subset:  IM    
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamil Nadu, India.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Bilirubin / metabolism
Blood Pressure / drug effects
Cholesterol / blood
Fibrinogen / drug effects
Hypertension / drug therapy*
Lipids / blood
Lipoprotein(a) / blood
Middle Aged
Obesity / drug therapy
Phytotherapy / methods*
Serum Albumin / drug effects
Treatment Outcome
Triglycerides / blood
Reg. No./Substance:
0/Antihypertensive Agents; 0/Lipids; 0/Lipoprotein(a); 0/Serum Albumin; 0/Tea; 0/Triglycerides; 57-88-5/Cholesterol; 635-65-4/Bilirubin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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