Document Detail

Effect of Mediterranean and Occidental diets, and red wine, on plasma fatty acids in humans. An intervention study.
MedLine Citation:
PMID:  15455655     Owner:  NLM     Status:  MEDLINE    
The type of diet consumed by individuals has been associated with the development of some chronic diseases, including cardiovascular disease (CVD), cancer, diabetes, and others. Populations that consume diets rich in fruits and vegetables and drink wine in moderation, as the Mediterranean, have a higher life expectancy and less chronic diseases than other occidental populations. We carried out an intervention study in humans to evaluate the effect of a Mediterranean diet (MD), an Occidental diet (OD) and their supplementation with red wine, on biochemical, physiological and clinical parameters related to atherosclerosis and other chronic diseases. For 3 months, two groups of 21 male volunteers each, received either a MD or an OD; during the second month, red wine was added isocalorically, 240 ml/day. At days 0, 30, 60 and 90, clinical, physiological and biochemical evaluations were made. In this article we report on the results obtained in plasma fatty acids profile that includes saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), omega-6 fatty acids, omega-3 fatty acids and omega-6/omega-3 ratio. Other results have been published previously. Plasma fatty acid percentages in the OD group, compared to the MD group, did not show differences in SFA, but the OD group showed lower levels of MUFA and omega-3 fatty acids, and higher levels of PUFA and omega-6 fatty acids, with a higher omega-6/omega-3 ratio than the MD group. Wine supplementation reduced MUFA and increased PUFA in both dietary groups, suggesting that wine could improve a diet with a good omega-6/omega-3 ratio. Volunteers on MD showed a better fatty acid profile than those on OD, suggesting a lower cardiovascular risk. Moderate consumption of wine improves this profile in the MD group.
Inés Urquiaga; Viviana Guasch; Guillermo Marshall; Alejandra San Martín; Oscar Castillo; Jaime Rozowski; Federico Leighton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological research     Volume:  37     ISSN:  0716-9760     ISO Abbreviation:  Biol. Res.     Publication Date:  2004  
Date Detail:
Created Date:  2004-09-30     Completed Date:  2005-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9308271     Medline TA:  Biol Res     Country:  Chile    
Other Details:
Languages:  eng     Pagination:  253-61     Citation Subset:  IM    
Molecular Nutrition Laboratory, Faculty of Biological Sciences, Catholic University of Chile, Santiago, Chile.
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MeSH Terms
Cardiovascular Diseases / prevention & control
Diet, Mediterranean*
Dietary Fats / administration & dosage*,  blood
Energy Intake
Fatty Acids / blood*
Hemostasis / drug effects
Risk Factors
Statistics, Nonparametric
Time Factors
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids

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