Document Detail


Effect of maternal body mass index on the retinal microvasculature in pregnancy.
MedLine Citation:
PMID:  22914473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To estimate the effects of maternal body mass index (BMI) and pregnancy weight gain on the retinal microvasculature among pregnant women.
METHODS: We studied 814 pregnant women aged 18-46 years who were recruited as part of the Growing Up in Singapore Toward Health Outcomes study, an ongoing birth cohort study from two government hospitals in Singapore since 2009. Recalled prepregnancy weight was recorded, and maternal anthropometric measurements of weight and height were performed at 26 weeks of gestation together with retinal photography.
RESULTS: In multiple linear regression models, each standard deviation increase of 26-week pregnancy BMI (4.57) was associated with narrower retinal arteriolar caliber (by 1.58 micrometers, P<.001), wider venular caliber (by 1.28 micrometers, P=.02), and increased retinal venular tortuosity (P=.01). Compared with mothers with normal weight, obese mothers (prepregnancy BMI greater than 30.0) had narrower retinal arteriolar caliber (118.81 compared with 123.38 micrometers, P<.001), wider retinal venular caliber (175.81 compared with 173.01 micrometers; P<.01), and increased retinal venular tortuosity (129.92 compared with 121.49 × 10(-6); P<.01). Pregnant women whose BMI-specific weight gain from prepregnancy to 26 weeks of gestation was above Institute of Medicine recommendations had narrower retinal arteriolar caliber (120.68 micrometers) than women with ideal (121.91 micrometers) and less than ideal weight gain (123.17), respectively (P trend=.05).
CONCLUSION: These data indicate that greater prepregnancy BMI and pregnancy BMI are associated with adverse retinal microvascular measures, suggesting that maternal obesity has an effect on her microcirculation.
Authors:
Ling-Jun Li; M Kamran Ikram; Carol Yim-Lui Cheung; Yung-Seng Lee; Lin-Jun Lee; Peter Gluckman; Keith M Godfrey; Yap-Seng Chong; Kenneth Kwek; Tien-Yin Wong; Seang-Mei Saw
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  120     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-23     Completed Date:  2012-10-29     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  627-35     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Body Mass Index*
Cohort Studies
Cross-Sectional Studies
Female
Humans
Linear Models
Microvessels / pathology*
Middle Aged
Obesity / pathology*
Photography
Pregnancy
Pregnancy Complications / pathology*
Retinal Vessels / pathology*
Singapore
Weight Gain*
Young Adult
Grant Support
ID/Acronym/Agency:
MC_UP_A620_1017//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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