Document Detail


Effect of material properties on predicted vesical pressure during a cough in a simplified computational model of the bladder and urethra.
MedLine Citation:
PMID:  22907256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stress urinary incontinence is a condition that affects mainly women and is characterized by the involuntary loss of urine in conjunction with an increase in abdominal pressure but in the absence of a bladder contraction. In spite of the large number of women affected by this condition, little is known regarding the mechanics associated with the maintenance of continence in women. Urodynamic measurements of the pressure acting on the bladder and the pressures developed within the bladder and the urethra offer a potential starting point for constructing computational models of the bladder and urethra during stress events. The measured pressures can be utilized in these models to provide information to specify loads and validate the models. The main goals of this study were to investigate the feasibility of incorporating human urodynamic pressure data into a computational model of the bladder and the urethra during a cough and determine if the resulting model could be validated through comparison of predicted and measured vesical pressure. The results of this study indicated that simplified models can predict vesical pressures that differ by less than 5 cmH(2)O (<10%) compared to urodynamic pressure measurements. In addition, varying material properties had a minimal impact on the vesical pressure and displacements predicted by the model. The latter finding limits the use of vesical pressure as a validation criterion since different parameters can yield similar results in the same model. However, the insensitivity of vesical pressure predictions to material properties ensures that the outcome of our models is not highly sensitive to tissue material properties, which are not well characterized.
Authors:
Thomas Spirka; Kimberly Kenton; Linda Brubaker; Margot S Damaser
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-08-21
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  41     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-05-28     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Computer Simulation
Cough / physiopathology*
Female
Finite Element Analysis
Humans
Middle Aged
Models, Biological*
Pressure
Urethra / physiology*
Urinary Bladder / physiology*
Urodynamics
Grant Support
ID/Acronym/Agency:
K23 HD047325/HD/NICHD NIH HHS; K23 HD047325-010/HD/NICHD NIH HHS; K24 DK064044/DK/NIDDK NIH HHS; K24 DK064044-03/DK/NIDDK NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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