Document Detail

Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats.
MedLine Citation:
PMID:  18814487     Owner:  NLM     Status:  MEDLINE    
Manuka honey (MH, 5g/kg) provided protection against trinitro-benzo-sulphonic acid induced colonic damage. Combination therapy (MH+sulfasalazine) also reduced colonic inflammation and all the biochemical parameters were significant compared to control and MH alone treated group. Combination therapy showed additive effect of the MH which restored lipid peroxidation and improvement of antioxidant parameters. Morphological and histological scores were significantly reduced in combination groups. In inflammatory model of colitis, oral administration of MH (5g/kg) and combination with sulfasalazine (360 mg/kg) with MH (5g/kg) significantly reduced the colonic inflammation. The results indicate the additive effect of Manuka honey with sulfasalazine in colitis.
B Medhi; A Prakash; P K Avti; U N Saikia; P Pandhi; K L Khanduja
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  46     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-25     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  583-90     Citation Subset:  IM    
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.
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MeSH Terms
Antioxidants / metabolism*
Colitis, Ulcerative / chemically induced,  drug therapy*,  metabolism*,  pathology
Disease Models, Animal
Rats, Wistar
Sulfasalazine / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Antioxidants; 599-79-1/Sulfasalazine

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