| Effect of Mannitol on Cerebral Blood Volume in Patients with Head Injury. | |
| | |
MedLine Citation:
|
PMID: 22089753 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Mannitol has traditionally been the mainstay of medical therapy for intracranial hypertension in patients with head injury. We previously demonstrated that mannitol reduces brain volume in patients with cerebral edema, although whether this occurs due to a reduction in brain water, blood volume or both remains poorly understood. OBJECTIVE: To test the hypothesis that mannitol acts by lowering blood viscosity leading to reflex vasoconstriction and a fall in cerebral blood volume (CBV). METHODS: We usedO PET to study six patients with traumatic brain injuries requiring treatment for intracranial hypertension. Cerebral blood flow (CBF), CBV and cerebral metabolic rate for oxygen (CMRO2) were measured before and one hour after administration of 1.0 g/kg 20% mannitol. RESULTS: CBV rose from 4.1 ± 0.4 to4.2 ± 0.2 ml/100g (p=0.3) while ICP fell from 21.5± 4.9 to 13.7±5.1 mm Hg (p< 0.003) after mannitol. Blood pressure,PaCO2, oxygen content, CBF and CMRO2did not change. CONCLUSION: A single bolus of 1 g/Kg of 20% mannitol does not acutely lower CBV. Another mechanism, such as a reduction in brain water, may better explain mannitol's ability to lower ICP and reduce mass effect. |
| | |
Authors:
|
Michael N Diringer; Michael T Scalfani; Allyson R Zazulia; Tom O Videen; Rajat Dhar; William J Powers |
Related Documents
:
|
16556883 - Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral ar... 17189353 - Interanimal variability in preexisting collaterals is a major factor determining outcom... 494643 - Perceptions of fatigue as related to alcohol ingestion. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-14 |
Journal Detail:
|
Title: Neurosurgery Volume: - ISSN: 1524-4040 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Departments of Neurology and Neurological Surgery1 Department of and Radiology2 Neurology/Neurosurgery Intensive Care Unit, Washington University School of Medicine, St. Louis MO, Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 3. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Occurrence and fate of androgens, estrogens, glucocorticoids and progestagens in two different types...
Next Document: Vein of Galen Malformations in Neonates: New Management Paradigms for Improving Outcomes.