| Effect of Low-dose, Enteric Coated Aspirin on Gastrointestinal Bleeding in Patients with Coronary Artery Disease. | |
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MedLine Citation:
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PMID: 20485618 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: This study was performed to determine whether low-dose aspirin and/or clopidogrel can induce gastrointestinal bleeding and gastroduodenal mucosal injury. METHODS: A total of 387 patients who underwent coronary angiography at Seoul National University Bundang Hospital were assigned to one of three antiplatelet treatment groups: (1) control, (2) 100-mg enteric coated aspirin, and (3) 100-mg enteric coated aspirin plus clopidogrel. The incidences of gastroduodenal mucosal injury and gastrointestinal bleeding were prospectively evaluated, and risk factors for gastrointestinal bleeding were analyzed. RESULTS: for gastrointestinal bleeding were analyzed. RESULTS: The rate of gastroduodenal mucosal injury was higher in the aspirin-plus-clopidogrel group than in the aspirin group (p=0.012), and higher in the aspirin group than in the control group (p=0.049). The rate of gastrointestinal bleeding was significantly higher in the aspirin-plus-clopidogrel group (9.4%) than in the control group (2.4%, p=0.048). The risk factors for gastrointestinal bleeding were older age (>/=60 years) and the presence of at least two comorbid disorders. CONCLUSIONS: Low-dose enteric coated aspirin was found to be safe in patients with coronary artery disease, but the addition of clopidogrel increased the rate of gastrointestinal bleeding. Combined clopidogrel and aspirin should be used with caution in older patients having at least two comorbid conditions. |
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Authors:
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Chang Kyu Choi; Nayoung Kim; Jin Woo Choi; Young Soo Park; Jin-Wook Kim; Sook-Hyang Jeong; Dong Ho Lee; Young-Seok Cho; Tae-Jin Youn; Woo-Young Chung; In-Ho Chae; Dong-Ju Choi |
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Publication Detail:
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Type: Journal Article Date: 2008-09-30 |
Journal Detail:
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Title: Gut and liver Volume: 2 ISSN: 1976-2283 ISO Abbreviation: Gut Liver Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2010-05-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101316452 Medline TA: Gut Liver Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 99-104 Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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